HitPredict

Interactor 1: RGAP1 (Q9H0H5)
Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4)
Gene: RACGAP1

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	26496610, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 632 Hs			1 639
+	Hs
		1285187 RGAP1_HUMAN (1-632): 0: 533: 100.00		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		924852 RGAP1_HUMAN (1-632): 0: 533: 100.00		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		1089312 RHG44_HUMAN (65-625): 8.78e-75: 257: 14.36		CD2AP_HUMAN (1-639): 9.29e-139: 420: 100.00
+	Hs
		1191674 SRGP1_HUMAN (14-627): 6.52e-93: 311: 12.74		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		1089305 RHG44_HUMAN (65-625): 8.78e-75: 257: 14.36		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		1066027 RHG44_HUMAN (65-625): 8.78e-75: 257: 14.36		ARHG6_HUMAN (52-634): 3.49e-68: 239: 13.68
+	Hs
		200200 SRGP3_HUMAN (1-627): 7.14e-96: 319: 13.81		SRGP2_HUMAN (2-443): 3.56e-43: 169: 11.52
+	Hs
		209014 CHIO_HUMAN (204-539): 4.25e-88: 283: 24.09		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17
+	Hs
		208987 CHIN_HUMAN (239-539): 1.23e-86: 279: 28.20		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17
+	Hs
		253374 SRGP1_HUMAN (14-627): 6.52e-93: 311: 12.74		SRGP2_HUMAN (2-443): 3.56e-43: 169: 11.52
+	Hs
		200212 SRGP3_HUMAN (1-627): 7.14e-96: 319: 13.81		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		253290 SRGP2_HUMAN (14-626): 2.29e-73: 257: 11.95		SRGP2_HUMAN (2-443): 3.56e-43: 169: 11.52
+	Hs
		1049716 SRGP1_HUMAN (14-627): 6.52e-93: 311: 12.74		ARHG7_HUMAN (176-378): 4.79e-13: 74.6: 20.87
+	Hs
		557642 CHIO_HUMAN (204-539): 4.25e-88: 283: 24.09		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Hs
		924608 Q1RLN5_HUMAN (329-541): 1.23e-64: 229: 27.44		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		551038 CHIN_HUMAN (239-539): 1.23e-86: 279: 28.20		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Dm
		1368053 RHGF_DROME (12-623): 3.46e-83: 283: 16.64		Q9VIN1_DROME (269-357): 7e-12: 70.7: 25.28
+	Hs
		253384 SRGP2_HUMAN (14-626): 2.29e-73: 257: 11.95		SH3R3_HUMAN (5-625): 1.58e-17: 88.8: 13.36
+	Hs
		253421 SRGP2_HUMAN (14-626): 2.29e-73: 257: 11.95		ITSN2_HUMAN (1-63): 2.7e-12: 72.2: 34.92