HitPredict

Interactor 1: WWP1 (Q9H0M0)
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)
Gene: WWP1

Interactor 2: LRP12 (Q9Y561)
Low-density lipoprotein receptor-related protein 12 (LDLR-related protein 12) (LRP-12) (Suppressor of tumorigenicity 7 protein)
Gene: LRP12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 922 Hs			1 859
+	Hs
		1190283 WWP1_HUMAN (1-922): 0: 953: 100.00		LRP10_HUMAN (3-297): 1.16e-11: 70.4: 15.02
+	Hs
		253908 ITCH_HUMAN (1-922): 0: 884: 57.14		LRP3_HUMAN (2-300): 2.81e-09: 63.1: 13.88
+	Hs
		270320 ITCH_HUMAN (1-922): 0: 884: 57.14		LRP6_HUMAN (394-488): 7.07e-09: 62: 32.32
+	Hs
		253910 NED4L_HUMAN (1-919): 0: 822: 33.16		LRP3_HUMAN (2-300): 2.81e-09: 63.1: 13.88
+	Dm
		247208 NEDD4_DROME (3-920): 0: 759: 30.21		TENM_DROME (3-289): 2.31e-19: 96.2: 11.57
+	Hs
		253886 NEDD4_HUMAN (84-919): 0: 723: 33.52		LRP3_HUMAN (2-300): 2.81e-09: 63.1: 13.88
+	Dm
		247320 Q9W325_DROME (502-922): 6.36e-171: 505: 43.79		TENM_DROME (3-289): 2.31e-19: 96.2: 11.57
+	Dm
		246947 SMUF1_DROME (16-538): 1.82e-25: 115: 13.02		TENM_DROME (3-289): 2.31e-19: 96.2: 11.57
+	Hs
		253919 HECW2_HUMAN (141-582): 1.9e-12: 73.8: 16.11		LRP3_HUMAN (2-300): 2.81e-09: 63.1: 13.88