HitPredict

Interactor 1: OSBL2 (Q9H1P3)
Oxysterol-binding protein-related protein 2 (ORP-2) (OSBP-related protein 2)
Gene: OSBPL2

Interactor 2: VAPA (Q9P0L0)
Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33)
Gene: VAPA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.665

Property	Details
Experiments	28514442, 33961781, 25681634
Identification Methods	affinity chromatography technology, bimolecular fluorescence complementation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0015914 - phospholipid transport GO:0030301 - cholesterol transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 480 Hs			1 249
+	Rn
		1225298 OSBL1_RAT (3-480): 0: 585: 64.94		VAPA_RAT (1-249): 3.22e-99: 291: 96.79
+	Hs
		1315823 OSBL1_HUMAN (3-480): 0: 574: 64.52		VAPA_HUMAN (1-249): 4.22e-100: 293: 100.00
+	Hs
		1122072 OSBL2_HUMAN (1-480): 0: 601: 100.00		Q53XM7_HUMAN (8-249): 3.73e-83: 250: 63.12
+	Hs
		310803 OSBL2_HUMAN (1-480): 0: 601: 100.00		VAPB_HUMAN (8-249): 3.73e-83: 250: 63.12
+	Hs
		310786 OSBL1_HUMAN (3-480): 0: 574: 64.52		VAPB_HUMAN (8-249): 3.73e-83: 250: 63.12
+	Hs
		1282120 OSBP2_HUMAN (1-480): 1.21e-168: 500: 34.80		VAPA_HUMAN (1-249): 4.22e-100: 293: 100.00
+	Hs
		1331232 OSBL3_HUMAN (2-470): 6.41e-166: 492: 36.95		VAPA_HUMAN (1-249): 4.22e-100: 293: 100.00
+	Hs
		1318032 OSBL6_HUMAN (2-470): 3.81e-161: 481: 35.98		VAPA_HUMAN (1-249): 4.22e-100: 293: 100.00
+	Hs
		603095 OSBP1_HUMAN (2-480): 4.47e-162: 480: 35.96		VAPA_HUMAN (1-249): 4.22e-100: 293: 100.00
+	Hs
		1318024 OSBL7_HUMAN (2-469): 2.08e-154: 461: 34.31		VAPA_HUMAN (1-249): 4.22e-100: 293: 100.00
+	Hs
		310745 OSBP2_HUMAN (1-480): 1.21e-168: 500: 34.80		VAPB_HUMAN (8-249): 3.73e-83: 250: 63.12
+	Hs
		310813 OSBL3_HUMAN (2-470): 6.41e-166: 492: 36.95		VAPB_HUMAN (8-249): 3.73e-83: 250: 63.12
+	Hs
		310792 OSBL6_HUMAN (2-470): 3.81e-161: 481: 35.98		VAPB_HUMAN (8-249): 3.73e-83: 250: 63.12
+	Hs
		310506 OSBP1_HUMAN (2-480): 4.47e-162: 480: 35.96		VAPB_HUMAN (8-249): 3.73e-83: 250: 63.12
+	Hs
		1245667 OSBL1_HUMAN (3-480): 0: 574: 64.52		MSPD2_HUMAN (14-190): 1.24e-39: 144: 19.34
+	At
		1258327 ORP2A_ARATH (2-480): 1.45e-172: 504: 34.75		VAP11_ARATH (8-214): 4.22e-67: 210: 25.11
+	Hs
		603075 OSBP1_HUMAN (2-480): 4.47e-162: 480: 35.96		MSPD2_HUMAN (14-190): 1.24e-39: 144: 19.34
+	Sc
		1015618 OSH2_YEAST (2-480): 6.95e-164: 498: 31.59		SCS22_YEAST (18-156): 3.77e-33: 120: 26.32
+	Sc
		767991 OSH2_YEAST (2-480): 6.95e-164: 498: 31.59		SCS2_YEAST (16-172): 2.69e-32: 119: 26.79
+	Sc
		728872 OSH1_YEAST (2-480): 2.95e-162: 491: 31.95		SCS2_YEAST (16-172): 2.69e-32: 119: 26.79