HitPredict

Interactor 1: EPN3 (Q9H201)
Epsin-3 (EPS-15-interacting protein 3)
Gene: EPN3

Interactor 2: TRIM1 (Q9UJV3)
Probable E3 ubiquitin-protein ligase MID2 (EC 2.3.2.27) (Midin-2) (Midline defect 2) (Midline-2) (RING finger protein 60) (RING-type E3 ubiquitin transferase MID2) (Tripartite motif-containing protein 1)
Gene: MID2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0070062 - extracellular exosome
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 632 Hs			1 735
+	Hs
		111205 I6L9I8_HUMAN (1-316): 1.19e-106: 326: 94.30		TRI18_HUMAN (21-717): 8.76e-175: 518: 72.60
+	Hs
		307570 EPN2_HUMAN (1-632): 5.11e-66: 229: 33.54		TRIM1_HUMAN (1-735): 0: 592: 100.00
+	Hs
		175713 EPN3_HUMAN (1-632): 1.32e-92: 300: 100.00		TRI18_HUMAN (21-717): 8.76e-175: 518: 72.60
+	Hs
		175627 EPN2_HUMAN (1-632): 5.11e-66: 229: 33.54		TRI18_HUMAN (21-717): 8.76e-175: 518: 72.60
+	Hs
		1057061 EPN4_HUMAN (3-628): 4.33e-76: 256: 21.77		TRI67_HUMAN (74-718): 5.93e-89: 297: 22.96
+	Hs
		307538 EPN2_HUMAN (1-632): 5.11e-66: 229: 33.54		TRI67_HUMAN (74-718): 5.93e-89: 297: 22.96
+	Hs
		1172486 EPN1_HUMAN (1-592): 3.16e-57: 204: 37.64		TRI67_HUMAN (74-718): 5.93e-89: 297: 22.96
+	Hs
		787934 EPS15_HUMAN (38-569): 4e-46: 177: 10.26		TRI67_HUMAN (74-718): 5.93e-89: 297: 22.96
+	Hs
		161678 GAK_HUMAN (173-548): 3.67e-40: 159: 16.46		TRI67_HUMAN (74-718): 5.93e-89: 297: 22.96
+	Hs
		867105 SC24C_HUMAN (287-632): 3.11e-12: 72.1: 12.00		TRI67_HUMAN (74-718): 5.93e-89: 297: 22.96
+	Hs
		203236 SYNJ1_HUMAN (291-630): 4.09e-11: 68.5: 12.15		TRI67_HUMAN (74-718): 5.93e-89: 297: 22.96
+	Hs
		307561 EPN2_HUMAN (1-632): 5.11e-66: 229: 33.54		TRI62_HUMAN (114-458): 1.79e-32: 133: 15.47
+	Hs
		1170060 SRCAP_HUMAN (307-630): 4.91e-09: 62: 12.09		TRI67_HUMAN (74-718): 5.93e-89: 297: 22.96
+	Hs
		1049027 EPN4_HUMAN (3-628): 4.33e-76: 256: 21.77		TRI14_HUMAN (192-413): 5.06e-11: 67.6: 19.30
+	Hs
		307511 EPN2_HUMAN (1-632): 5.11e-66: 229: 33.54		TRI23_HUMAN (28-272): 6.41e-17: 86.7: 24.71
+	Hs
		734550 EPS15_HUMAN (38-569): 4e-46: 177: 10.26		TRI23_HUMAN (28-272): 6.41e-17: 86.7: 24.71
+	Hs
		1170080 SRCAP_HUMAN (307-630): 4.91e-09: 62: 12.09		TRI54_HUMAN (184-400): 2.63e-53: 190: 23.96