HitPredict - High confidence protein-protein interactions

Interactor 1: CARD9 (Q9H257)
Caspase recruitment domain-containing protein 9 (hCARD9)
Gene: CARD9

Interactor 2: NOD2 (Q9HC29)
Nucleotide-binding oligomerization domain-containing protein 2 (Caspase recruitment domain-containing protein 15) (Inflammatory bowel disease protein 1)
Gene: NOD2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	17187069, 24960071
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CARD~CARD
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007254 - JNK cascade GO:0032495 - response to muramyl dipeptide and 15 others more... GO:0032740 - positive regulation of interleukin-17 production GO:0032755 - positive regulation of interleukin-6 production GO:0032760 - positive regulation of tumor necrosis factor production GO:0032874 - positive regulation of stress-activated MAPK cascade GO:0032991 - protein-containing complex GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0043330 - response to exogenous dsRNA GO:0046330 - positive regulation of JNK cascade GO:0048874 - host-mediated regulation of intestinal microbiota composition GO:0050700 - CARD domain binding GO:0051092 - positive regulation of NF-kappaB transcription factor activity GO:0051403 - stress-activated MAPK cascade GO:0060907 - positive regulation of macrophage cytokine production GO:0070374 - positive regulation of ERK1 and ERK2 cascade GO:1900017 - positive regulation of cytokine production involved in inflammatory response
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	536
Hs

1	1040

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Last updated: 15 Jul 2024