HitPredict

Interactor 1: SDCB1 (O00560)
Syntenin-1 (Melanoma differentiation-associated protein 9) (MDA-9) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18) (Scaffold protein Pbp1) (Syndecan-binding protein 1)
Gene: SDCBP

Interactor 2: RHOU (Q7L0Q8)
Rho-related GTP-binding protein RhoU (CDC42-like GTPase 1) (GTP-binding protein-like 1) (Rho GTPase-like protein ARHU) (Ryu GTPase) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1)
Gene: RHOU

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 298 Hs			1 258
+	Hs
		132717 SDCB1_HUMAN (1-298): 8.79e-106: 311: 100.00		RHOC_HUMAN (51-231): 3.2e-89: 264: 46.96
+	Hs
		132804 SDCB1_HUMAN (1-298): 8.79e-106: 311: 100.00		RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96
+	Hs
		132816 SDCB1_HUMAN (1-298): 8.79e-106: 311: 100.00		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		132811 SDCB1_HUMAN (1-298): 8.79e-106: 311: 100.00		RB11A_HUMAN (39-256): 1.13e-77: 235: 26.87
+	Hs
		132808 SDCB1_HUMAN (1-298): 8.79e-106: 311: 100.00		RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15
+	Hs
		132735 SDCB1_HUMAN (1-298): 8.79e-106: 311: 100.00		RAC2_HUMAN (50-233): 5.11e-77: 233: 56.52
+	Hs
		132805 SDCB1_HUMAN (1-298): 8.79e-106: 311: 100.00		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82
+	Hs
		132739 SDCB1_HUMAN (1-298): 8.79e-106: 311: 100.00		RHOQ_HUMAN (50-221): 2.69e-66: 206: 56.40
+	Hs
		133021 SDCB1_HUMAN (1-298): 8.79e-106: 311: 100.00		RHOJ_HUMAN (40-238): 2.64e-63: 199: 51.26
+	Hs
		951099 PREX2_HUMAN (108-256): 2.7e-39: 148: 20.40		RHOG_HUMAN (48-233): 5.28e-83: 248: 48.93
+	Mm
		914511 APBA2_MOUSE (107-287): 3.13e-42: 156: 23.81		RB11A_MOUSE (39-256): 1.13e-77: 235: 26.87
+	Hs
		925382 PREX2_HUMAN (108-256): 2.7e-39: 148: 20.40		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		900616 PREX2_HUMAN (108-256): 2.7e-39: 148: 20.40		RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15
+	Hs
		894155 PREX2_HUMAN (108-256): 2.7e-39: 148: 20.40		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82
+	Mm
		1111996 DLG4_MOUSE (193-286): 2.27e-16: 81.4: 24.75		Q3TLP8_MOUSE (48-234): 1.52e-89: 265: 50.49
+	Hs
		892525 DLG3_HUMAN (184-268): 1.4e-17: 84.8: 26.09		RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96
+	Hs
		951207 DLG3_HUMAN (184-268): 1.4e-17: 84.8: 26.09		RHOG_HUMAN (48-233): 5.28e-83: 248: 48.93
+	Mm
		925797 DLG4_MOUSE (193-286): 2.27e-16: 81.4: 24.75		RAC1_MOUSE (50-234): 2.11e-79: 239: 56.76
+	Hs
		900762 DLG3_HUMAN (184-268): 1.4e-17: 84.8: 26.09		RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15
+	Hs
		564636 DLG3_HUMAN (184-268): 1.4e-17: 84.8: 26.09		RHOQ_HUMAN (50-221): 2.69e-66: 206: 56.40