HitPredict

Interactor 1: SLK (Q9H2G2)
STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2)
Gene: SLK

Interactor 2: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Pkinase
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1235 Hs			1 779
+	Hs
		149286 CTRO_HUMAN (8-1230): 4.15e-145: 486: 15.52		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1331386 SNRK_HUMAN (27-738): 6.02e-125: 405: 16.78		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		610780 KAPCB_HUMAN (2-343): 6.64e-126: 393: 23.86		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		296421 STK10_HUMAN (1-1000): 9.75e-115: 383: 32.25		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1039170 KCC2D_HUMAN (31-423): 9.26e-116: 371: 27.25		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		850712 KS6A3_HUMAN (22-342): 5.85e-95: 323: 22.49		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Ce
		136783 O17566_CAEEL (1-1207): 2.21e-165: 526: 27.57		UNC89_CAEEL (146-660): 3.62e-58: 218: 12.35
+	Hs
		1331724 M4K5_HUMAN (29-292): 6.48e-62: 230: 44.74		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		148966 CTRO_HUMAN (8-1230): 4.15e-145: 486: 15.52		MPRIP_HUMAN (2-499): 4.76e-44: 173: 16.57
+	Hs
		148935 CTRO_HUMAN (8-1230): 4.15e-145: 486: 15.52		CYTSA_HUMAN (320-643): 3.92e-43: 171: 12.81
+	Hs
		149443 CTRO_HUMAN (8-1230): 4.15e-145: 486: 15.52		PKHA6_HUMAN (3-364): 2.39e-40: 162: 26.02
+	Mm
		515244 KCC2A_MOUSE (31-423): 4.29e-113: 364: 25.00		CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40
+	Rn
		506782 KCC2A_RAT (31-423): 4.29e-113: 364: 25.00		CNKR2_RAT (1-468): 2.97e-47: 183: 14.20
+	Hs
		1022390 KCC2D_HUMAN (31-423): 9.26e-116: 371: 27.25		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Rn
		506741 KCC2A_RAT (31-423): 4.29e-113: 364: 25.00		CAPS1_RAT (11-428): 1.59e-46: 181: 10.23
+	Hs
		1334862 KCC2A_HUMAN (31-423): 1.9e-113: 364: 25.25		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		1071703 KS6A2_HUMAN (22-353): 4.19e-97: 328: 22.65		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		787158 KCC2D_HUMAN (31-423): 9.26e-116: 371: 27.25		RHG25_HUMAN (30-181): 1.01e-21: 102: 23.27
+	Hs
		1018193 M4K2_HUMAN (29-293): 8.36e-66: 241: 45.32		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		1027413 STK3_HUMAN (30-307): 1.02e-62: 224: 43.42		CNKR1_HUMAN (17-260): 6.93e-38: 153: 22.84