Interactor 1: P63 (Q9H3D4)
Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51)
Gene: TP63

Interactor 2: P63 (Q9H3D4)
Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51)
Gene: TP63

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.81 1.00 0.902

The method score is based on:

Property Details
Experiments 20085233, 19815500, 21464285, 21335238
Identification Methods affinity chromatography technology, mass spectrometry studies of complexes, cosedimentation in solution, x-ray crystallography, anti tag coimmunoprecipitation, nuclear magnetic resonance
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains P53~P53, P53~P53_tetramer, P53_tetramer~P53_tetramer, SAM_2~SAM_2
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
and 65 others

more...

Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 680
Hs

1 680
+ Mm
+ Hs
+ Mm
+ Hs
+ Mm
+ Mm
+ Hs
+ Mm
+ Hs
+ Mm
+ Dr
+ Dr
+ Hs
+ Dm

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Last updated: 15 Jul 2024