HitPredict

Interactor 1: MLP3A (Q9H492)
Microtubule-associated proteins 1A/1B light chain 3A (Autophagy-related protein LC3 A) (Autophagy-related ubiquitin-like modifier LC3 A) (MAP1 light chain 3-like protein 1) (MAP1A/MAP1B light chain 3 A) (MAP1A/MAP1B LC3 A) (Microtubule-associated protein 1 light chain 3 alpha)
Gene: MAP1LC3A

Interactor 2: ATG3 (Q9NT62)
Ubiquitin-like-conjugating enzyme ATG3 (EC 2.3.2.-) (Autophagy-related protein 3) (APG3-like) (hApg3) (Protein PC3-96)
Gene: ATG3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.746

Property	Details
Experiments	25601754, 36576150, 20562859, 20061800, 16303767, 25503391, 19838173
Identification Methods	affinity chromatography technology, pull down, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000045 - autophagosome assembly GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 121 Hs			1 314
+	Mm
		1265087 MLP3A_MOUSE (1-121): 4.19e-54: 167: 100.00		ATG3_MOUSE (1-314): 2.92e-158: 446: 97.45
+	Hs
		891336 GBRL2_HUMAN (7-121): 5.54e-54: 166: 41.74		ATG3_HUMAN (1-314): 1.12e-158: 446: 100.00
+	Hs
		1326176 MLP3B_HUMAN (1-121): 6.65e-52: 161: 81.82		ATG3_HUMAN (1-314): 1.12e-158: 446: 100.00
+	Hs
		306334 GBRAP_HUMAN (7-121): 2.99e-52: 161: 30.44		ATG3_HUMAN (1-314): 1.12e-158: 446: 100.00
+	Hs
		1315807 MLP3C_HUMAN (1-120): 5.63e-51: 159: 59.17		ATG3_HUMAN (1-314): 1.12e-158: 446: 100.00
+	Hs
		61904 MP3B2_HUMAN (1-121): 4.06e-51: 159: 80.99		ATG3_HUMAN (1-314): 1.12e-158: 446: 100.00
+	Hs
		1328043 GBRL1_HUMAN (3-120): 5.97e-51: 158: 33.05		ATG3_HUMAN (1-314): 1.12e-158: 446: 100.00
+	At
		1013368 ATG8F_ARATH (3-121): 2.51e-58: 177: 35.29		ATG3_ARATH (17-314): 8.92e-122: 353: 46.41
+	Ce
		999358 LGG1_CAEEL (6-120): 1.79e-50: 157: 33.91		Q9N369_CAEEL (1-314): 2.55e-119: 347: 49.22
+	Ce
		1095400 LGG2_CAEEL (6-120): 4.95e-44: 141: 59.13		Q9N369_CAEEL (1-314): 2.55e-119: 347: 49.22
+	Pf
		83078 Q8IJK2_PLAF7 (6-120): 4.23e-45: 144: 32.26		C0H519_PLAF7 (3-314): 9.8e-111: 325: 37.11
+	Sc
		745998 ATG8_YEAST (3-120): 2.38e-54: 167: 35.59		ATG3_YEAST (8-311): 1.53e-97: 291: 33.13
+	Mm
		1246814 MLP3B_MOUSE (1-120): 3.16e-52: 162: 82.50		ATG10_MOUSE (173-301): 3.9e-44: 151: 20.59
+	Hs
		891316 GBRL2_HUMAN (7-121): 5.54e-54: 166: 41.74		ATG10_HUMAN (173-301): 3.27e-41: 144: 20.59
+	Hs
		1326136 MLP3B_HUMAN (1-121): 6.65e-52: 161: 81.82		ATG10_HUMAN (173-301): 3.27e-41: 144: 20.59
+	Hs
		306312 GBRAP_HUMAN (7-121): 2.99e-52: 161: 30.44		ATG10_HUMAN (173-301): 3.27e-41: 144: 20.59
+	Hs
		1315801 MLP3C_HUMAN (1-120): 5.63e-51: 159: 59.17		ATG10_HUMAN (173-301): 3.27e-41: 144: 20.59
+	Hs
		61902 MP3B2_HUMAN (1-121): 4.06e-51: 159: 80.99		ATG10_HUMAN (173-301): 3.27e-41: 144: 20.59
+	Hs
		1328025 GBRL1_HUMAN (3-120): 5.97e-51: 158: 33.05		ATG10_HUMAN (173-301): 3.27e-41: 144: 20.59