HitPredict

Interactor 1: MLP3A (Q9H492)
Microtubule-associated proteins 1A/1B light chain 3A (Autophagy-related protein LC3 A) (Autophagy-related ubiquitin-like modifier LC3 A) (MAP1 light chain 3-like protein 1) (MAP1A/MAP1B light chain 3 A) (MAP1A/MAP1B LC3 A) (Microtubule-associated protein 1 light chain 3 alpha)
Gene: MAP1LC3A

Interactor 2: ATG4B (Q9Y4P1)
Cysteine protease ATG4B (EC 3.4.22.-) (AUT-like 1 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 1) (Autophagin-1) (Autophagy-related protein 4 homolog B) (HsAPG4B) (hAPG4B)
Gene: ATG4B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.967

The method score is based on:

Property Details
Experiments 28287329, 32296183, 20562859, 19549685, 16183633, 19322194, 15187094, unassigned1304
Identification Methods pull down, two hybrid, affinity chromatography technology, enzymatic study, x-ray crystallography, protease assay, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association, protein cleavage

The annotation score is based on:

Property Details
Interacting Pfam domains ATG8~Peptidase_C54
Common GO terms GO:0000045 - autophagosome assembly
GO:0000421 - autophagosome membrane
GO:0005829 - cytosol
GO:0016236 - macroautophagy
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 121
Hs

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Last updated: 15 Jul 2024