HitPredict

Interactor 1: WNK1 (Q9H4A3)
Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1)
Gene: WNK1

Interactor 2: WNK2 (Q9Y3S1)
Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43)
Gene: WNK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.66 1.00 0.817

The method score is based on:

Property Details
Experiments 35271311, 20936779
Identification Methods affinity chromatography technology, two hybrid, two hybrid pooling approach, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains OSR1_C~Pkinase, Pkinase~Pkinase
Common GO terms GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006468 - protein phosphorylation
and 6 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 2382
Hs

1 2297
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024