HitPredict

Interactor 1: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Interactor 2: ECT2 (Q9H8V3)
Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene)
Gene: ECT2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~RhoGEF
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 779 Hs			1 914
+	Hs
		1333813 TBD2B_HUMAN (53-512): 3.31e-51: 195: 17.57		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		1167428 MPRIP_HUMAN (2-499): 4.76e-44: 173: 16.57		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		1133706 RHG21_HUMAN (22-662): 1.96e-43: 172: 13.18		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		1148973 CYTSA_HUMAN (320-643): 3.92e-43: 171: 12.81		ECT2_HUMAN (1-914): 0: 886: 100.00
+	Hs
		1266884 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		TOPB1_HUMAN (92-458): 8.82e-90: 314: 23.10
+	Hs
		1273277 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		ARHG2_HUMAN (249-775): 2e-83: 291: 15.02
+	Hs
		1331486 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		ARHGC_HUMAN (316-874): 1.5e-78: 281: 16.35
+	Hs
		855823 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		VAV2_HUMAN (386-707): 7.77e-69: 248: 18.94
+	Hs
		1021852 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		ABR_HUMAN (463-641): 7.42e-16: 84.3: 30.27
+	Hs
		506659 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		BCR_HUMAN (453-641): 1.17e-14: 80.9: 27.69
+	Hs
		548703 GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92		VAV_HUMAN (390-707): 1.61e-76: 269: 21.82
+	Hs
		50598 PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02		PKHG3_HUMAN (394-892): 2.49e-76: 273: 18.53
+	Mm
		1194490 CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40		ARHG7_MOUSE (309-913): 2.98e-80: 279: 11.35
+	Hs
		1035413 GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92		VAV3_HUMAN (382-707): 3.15e-73: 260: 22.58
+	Hs
		855792 GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92		VAV2_HUMAN (386-707): 7.77e-69: 248: 18.94
+	Hs
		548722 CYTSA_HUMAN (320-643): 3.92e-43: 171: 12.81		VAV_HUMAN (390-707): 1.61e-76: 269: 21.82
+	Hs
		200789 PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61		ARHG9_HUMAN (404-798): 2.6e-76: 260: 19.36
+	Ce
		136804 UNC89_CAEEL (146-660): 3.62e-58: 218: 12.35		VAV_CAEEL (453-712): 7.03e-14: 78.2: 26.92
+	Hs
		164119 TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28		ARHGA_HUMAN (436-704): 1.71e-23: 109: 29.33
+	Hs
		167092 MPRIP_HUMAN (2-499): 4.76e-44: 173: 16.57		ARHGB_HUMAN (453-651): 2.54e-12: 73.2: 23.53