HitPredict

Interactor 1: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Interactor 2: KBRS2 (Q9NYR9)
NF-kappa-B inhibitor-interacting Ras-like protein 2 (I-kappa-B-interacting Ras-like protein 2) (Kappa B-Ras protein 2) (KappaB-Ras2)
Gene: NKIRAS2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 779 Hs			1 191
+	Hs
		918949 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		RAB1A_HUMAN (5-185): 1.07e-71: 217: 22.65
+	Hs
		895273 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		RAB2A_HUMAN (5-185): 3.43e-71: 216: 19.89
+	Hs
		1328144 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		RAB1B_HUMAN (5-184): 4.89e-71: 215: 21.67
+	Hs
		914357 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		RB11A_HUMAN (5-183): 5.92e-70: 213: 24.02
+	Hs
		1331603 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		RAB21_HUMAN (4-188): 6.91e-12: 63.5: 28.11
+	Hs
		349293 GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92		RASH_HUMAN (17-190): 5.34e-75: 225: 25.29
+	Hs
		506411 CNKR2_HUMAN (1-468): 1.39e-46: 181: 13.77		RALA_HUMAN (6-176): 1.39e-76: 229: 26.32
+	Hs
		914051 GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92		RB11A_HUMAN (5-183): 5.92e-70: 213: 24.02
+	Hs
		914465 TBD2B_HUMAN (53-512): 3.31e-51: 195: 17.57		RB11A_HUMAN (5-183): 5.92e-70: 213: 24.02
+	Hs
		349120 RASA1_HUMAN (72-437): 2.74e-44: 174: 11.32		RASH_HUMAN (17-190): 5.34e-75: 225: 25.29
+	Hs
		349282 TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28		RASH_HUMAN (17-190): 5.34e-75: 225: 25.29
+	Hs
		349384 RHG21_HUMAN (22-662): 1.96e-43: 172: 13.18		RASH_HUMAN (17-190): 5.34e-75: 225: 25.29
+	Ce
		107453 Q23419_CAEEL (46-578): 5.81e-41: 163: 12.59		G5EFC1_CAEEL (1-190): 2.22e-77: 231: 22.68
+	Hs
		895058 TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28		RAB2A_HUMAN (5-185): 3.43e-71: 216: 19.89
+	Hs
		895119 RHG21_HUMAN (22-662): 1.96e-43: 172: 13.18		RAB2A_HUMAN (5-185): 3.43e-71: 216: 19.89
+	Hs
		894736 ACAP2_HUMAN (28-517): 6.24e-39: 156: 13.10		RAB8A_HUMAN (1-187): 2.04e-77: 231: 23.04
+	Hs
		914432 SWP70_HUMAN (55-446): 3.06e-44: 170: 11.36		RB11A_HUMAN (5-183): 5.92e-70: 213: 24.02
+	Hs
		349655 PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61		RASH_HUMAN (17-190): 5.34e-75: 225: 25.29
+	Hs
		914370 PKHA1_HUMAN (16-261): 3.76e-39: 151: 16.92		RB11A_HUMAN (5-183): 5.92e-70: 213: 24.02
+	Ce
		1095340 Q23419_CAEEL (46-578): 5.81e-41: 163: 12.59		Q9U2C3_CAEEL (6-175): 8.05e-11: 60.5: 28.25