HitPredict

Interactor 1: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Interactor 2: E2AK4 (Q9P2K8)
eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein)
Gene: EIF2AK4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Pkinase
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 779 Hs			1 1649
+	Hs
		829335 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		SYHM_HUMAN (1001-1492): 3.35e-129: 414: 22.24
+	Hs
		270445 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		KS6A5_HUMAN (725-1230): 3.21e-110: 372: 13.68
+	Hs
		1073480 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		KS6A1_HUMAN (540-1048): 1.73e-89: 310: 15.24
+	Hs
		850712 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		KS6A3_HUMAN (540-1020): 1.3e-89: 310: 15.35
+	Hs
		272901 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		KS6A4_HUMAN (25-541): 2.75e-72: 260: 13.40
+	Hs
		1039170 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		KCC2D_HUMAN (11-208): 3.9e-30: 128: 12.56
+	Hs
		1039032 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		KCC2G_HUMAN (11-208): 2.57e-28: 124: 12.08
+	Hs
		585558 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		E2AK2_HUMAN (761-1012): 1.66e-24: 112: 35.04
+	Dm
		1099859 OSP_DROME (28-502): 3.43e-44: 174: 17.30		Q8IQX8_DROME (1054-1492): 3.6e-120: 391: 22.65
+	Hs
		1071703 PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61		KS6A2_HUMAN (634-1044): 1.25e-87: 305: 16.63
+	Mm
		659464 CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40		KCC2B_MOUSE (11-208): 4.14e-30: 129: 14.01
+	Mm
		515244 CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40		KCC2A_MOUSE (11-208): 1.51e-29: 126: 12.56
+	Rn
		506782 CNKR2_RAT (1-468): 2.97e-47: 183: 14.20		KCC2A_RAT (11-208): 1.51e-29: 126: 12.56
+	Rn
		506741 CAPS1_RAT (11-428): 1.59e-46: 181: 10.23		KCC2A_RAT (11-208): 1.51e-29: 126: 12.56
+	Hs
		1022390 TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28		KCC2D_HUMAN (11-208): 3.9e-30: 128: 12.56
+	Hs
		1334862 PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61		KCC2A_HUMAN (11-208): 1.52e-29: 126: 12.56
+	Hs
		787158 RHG25_HUMAN (30-181): 1.01e-21: 102: 23.27		KCC2D_HUMAN (11-208): 3.9e-30: 128: 12.56
+	Hs
		787157 RHG25_HUMAN (30-181): 1.01e-21: 102: 23.27		KCC2G_HUMAN (11-208): 2.57e-28: 124: 12.08