HitPredict

Interactor 1: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Interactor 2: TBK1 (Q9UHD2)
Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
Gene: TBK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Pkinase
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 779 Hs			1 729
+	Hs
		158545 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		IKKB_HUMAN (9-727): 1.01e-139: 430: 18.98
+	Hs
		254513 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		ROCK2_HUMAN (7-724): 1.1e-114: 378: 16.52
+	Hs
		1137906 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		MRCKA_HUMAN (6-698): 6.44e-109: 365: 17.31
+	Hs
		1331749 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		MRCKB_HUMAN (6-700): 1.77e-108: 364: 16.10
+	Hs
		625600 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		CDK2_HUMAN (6-312): 1.71e-119: 361: 20.97
+	Hs
		1331496 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		MARK1_HUMAN (9-407): 5.07e-87: 292: 23.33
+	Hs
		647959 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		MARK3_HUMAN (9-267): 1.86e-85: 287: 28.08
+	Hs
		1331234 OSBL3_HUMAN (52-563): 4.71e-44: 173: 11.36		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Hs
		625526 CNKR2_HUMAN (1-468): 1.39e-46: 181: 13.77		CDK2_HUMAN (6-312): 1.71e-119: 361: 20.97
+	Hs
		625495 MPRIP_HUMAN (2-499): 4.76e-44: 173: 16.57		CDK2_HUMAN (6-312): 1.71e-119: 361: 20.97
+	Hs
		625491 CYTSA_HUMAN (320-643): 3.92e-43: 171: 12.81		CDK2_HUMAN (6-312): 1.71e-119: 361: 20.97
+	Sc
		606187 OSH2_YEAST (2-703): 2.25e-55: 208: 10.89		RAD53_YEAST (10-221): 1.29e-22: 105: 31.65