HitPredict

Interactor 1: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Interactor 2: GIT1 (Q9Y2X7)
ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1)
Gene: GIT1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ArfGap~PH
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 779 Hs			1 761
+	Hs
		1050153 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		GIT2_HUMAN (1-758): 2.93e-147: 451: 64.39
+	Hs
		60417 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		POTEF_HUMAN (31-683): 7.43e-63: 230: 13.13
+	Mm
		1148423 CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40		GIT1_MOUSE (1-761): 7.5e-170: 509: 96.62
+	Hs
		167015 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		ANR28_HUMAN (52-250): 1.89e-18: 92.5: 11.06
+	Hs
		1153256 PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02		POTEE_HUMAN (31-683): 6.72e-62: 227: 12.90
+	Hs
		1153457 PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02		AGAP1_HUMAN (2-223): 4.13e-57: 211: 32.89
+	Hs
		1022473 TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28		AGAP1_HUMAN (2-223): 4.13e-57: 211: 32.89
+	Mm
		1112606 CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40		AGAP2_MOUSE (2-223): 9.71e-49: 188: 29.28
+	Hs
		596403 RASA1_HUMAN (72-437): 2.74e-44: 174: 11.32		ACAP2_HUMAN (2-331): 3.4e-53: 199: 18.50
+	Hs
		1167408 MPRIP_HUMAN (2-499): 4.76e-44: 173: 16.57		AGAP2_HUMAN (2-223): 3.67e-52: 198: 32.00
+	Hs
		1334860 PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61		AGAP1_HUMAN (2-223): 4.13e-57: 211: 32.89
+	Hs
		1190998 RHG22_HUMAN (29-181): 1.62e-33: 139: 26.95		AGAP3_HUMAN (2-223): 6.5e-55: 205: 34.22
+	Hs
		1021392 TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28		ANK3_HUMAN (93-695): 4.85e-40: 162: 12.34
+	Hs
		1021414 RHG21_HUMAN (22-662): 1.96e-43: 172: 13.18		ANK3_HUMAN (93-695): 4.85e-40: 162: 12.34
+	Hs
		1231287 RHG24_HUMAN (55-181): 6.43e-27: 119: 25.93		ARAP2_HUMAN (7-223): 6.18e-51: 195: 27.15
+	Hs
		965125 MPRIP_HUMAN (2-499): 4.76e-44: 173: 16.57		ANK2_HUMAN (162-494): 7.25e-30: 129: 9.52
+	Hs
		1021423 RHG22_HUMAN (29-181): 1.62e-33: 139: 26.95		ANK3_HUMAN (93-695): 4.85e-40: 162: 12.34
+	Hs
		556699 TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28		ANK1_HUMAN (163-647): 1.66e-27: 122: 10.92
+	Hs
		965158 PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61		ANK2_HUMAN (162-494): 7.25e-30: 129: 9.52
+	Hs
		1066128 ACAP2_HUMAN (28-517): 6.24e-39: 156: 13.10		ACAP3_HUMAN (11-111): 3.42e-14: 78.6: 41.51