HitPredict

Interactor 1: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Interactor 2: M4K5 (Q9Y4K4)
Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5)
Gene: MAP4K5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 779 Hs			1 846
+	Hs
		1039170 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		KCC2D_HUMAN (8-517): 1.77e-144: 437: 18.38
+	Hs
		1057200 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		MELK_HUMAN (20-615): 3.46e-137: 424: 19.44
+	Hs
		647959 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		MARK3_HUMAN (13-559): 3.08e-135: 422: 18.71
+	Hs
		1038924 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		KCC2B_HUMAN (8-488): 3.68e-127: 398: 22.27
+	Hs
		682210 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		AKT2_HUMAN (1-350): 8.02e-130: 398: 22.63
+	Hs
		1183121 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		MARK2_HUMAN (2-473): 3.58e-124: 394: 21.36
+	Hs
		682023 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		AKT1_HUMAN (12-346): 6.18e-125: 386: 22.38
+	Hs
		1023113 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		STK4_HUMAN (10-278): 1.36e-120: 375: 45.93
+	Hs
		1027433 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		STK3_HUMAN (1-408): 2.41e-120: 374: 32.45
+	Hs
		1331504 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		STK26_HUMAN (7-302): 4.07e-119: 368: 43.43
+	Hs
		1331766 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		STK24_HUMAN (8-379): 1.48e-118: 368: 37.53
+	Hs
		131607 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		STK25_HUMAN (8-407): 3.38e-118: 366: 37.91
+	Hs
		1331590 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		TNIK_HUMAN (14-295): 1.26e-72: 262: 45.73
+	Hs
		1233543 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		MINK1_HUMAN (3-295): 3.13e-70: 254: 45.28
+	Hs
		296421 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		STK10_HUMAN (15-286): 4.12e-66: 240: 45.46
+	Hs
		324878 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		M4K4_HUMAN (2-295): 4.04e-64: 236: 43.51
+	Sc
		419871 OSH3_YEAST (21-718): 7.21e-65: 235: 11.98		SNF1_YEAST (7-561): 1.99e-132: 410: 17.35
+	Mm
		515244 CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40		KCC2A_MOUSE (8-488): 2.27e-138: 420: 19.47
+	Hs
		1035386 GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92		MARK2_HUMAN (2-473): 3.58e-124: 394: 21.36
+	Hs
		681831 GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92		AKT1_HUMAN (12-346): 6.18e-125: 386: 22.38