HitPredict

Interactor 1: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Interactor 2: MRCKB (Q9Y5S2)
Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta)
Gene: CDC42BPB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~PH, PH~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 779 Hs			1 1711
+	Hs
		1137906 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		MRCKA_HUMAN (1-1710): 0: 1386: 60.78
+	Hs
		149286 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		CTRO_HUMAN (5-1085): 8.52e-127: 442: 24.93
+	Hs
		296421 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		STK10_HUMAN (43-1015): 1.26e-120: 406: 16.50
+	Hs
		623884 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		KPCL_HUMAN (70-408): 3.92e-119: 393: 34.01
+	Hs
		1069651 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		STK38_HUMAN (4-421): 5.25e-119: 385: 38.77
+	Hs
		568795 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		KAPCA_HUMAN (48-375): 1.99e-119: 382: 34.72
+	Hs
		610780 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		KAPCB_HUMAN (50-375): 2.2e-119: 382: 35.52
+	Hs
		1331590 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		TNIK_HUMAN (52-833): 5.89e-94: 336: 14.30
+	Hs
		1073480 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		KS6A1_HUMAN (2-354): 1.8e-89: 310: 22.16
+	Hs
		148966 MPRIP_HUMAN (2-499): 4.76e-44: 173: 16.57		CTRO_HUMAN (5-1085): 8.52e-127: 442: 24.93
+	Mm
		1169650 CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40		TAOK2_MOUSE (50-929): 2.77e-126: 429: 16.08
+	Hs
		148935 CYTSA_HUMAN (320-643): 3.92e-43: 171: 12.81		CTRO_HUMAN (5-1085): 8.52e-127: 442: 24.93
+	Hs
		254513 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		ROCK2_HUMAN (362-1073): 2.09e-23: 110: 13.59
+	Hs
		568704 PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02		KAPCA_HUMAN (48-375): 1.99e-119: 382: 34.72
+	Rn
		1144020 CAPS1_RAT (11-428): 1.59e-46: 181: 10.23		AKT3_RAT (17-411): 1.89e-120: 389: 29.75
+	Hs
		1035207 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		ROCK1_HUMAN (360-1074): 6.44e-17: 89.6: 13.02
+	Mm
		949351 CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40		TNIK_MOUSE (52-836): 1.02e-93: 335: 13.91
+	Hs
		1263851 CNKR2_HUMAN (1-468): 1.39e-46: 181: 13.77		TNIK_HUMAN (52-833): 5.89e-94: 336: 14.30
+	Hs
		1153402 PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02		LATS2_HUMAN (66-375): 4.05e-70: 259: 40.34
+	Hs
		1035167 GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92		ROCK1_HUMAN (360-1074): 6.44e-17: 89.6: 13.02