HitPredict

Interactor 1: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Interactor 2: BIG2 (Q9Y6D5)
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2)
Gene: ARFGEF2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Sec7
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 779 Hs			1 1785
+	Hs
		1331765 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		BIG1_HUMAN (5-1773): 0: 1816: 73.84
+	Hs
		1150560 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		IQEC1_HUMAN (568-881): 4.72e-84: 300: 29.13
+	Hs
		1266554 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		GBF1_HUMAN (1280-1510): 1.07e-43: 177: 13.31
+	Hs
		1189558 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		MON2_HUMAN (11-228): 1.82e-35: 150: 14.61
+	Hs
		1136956 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		BIG3_HUMAN (15-231): 2.83e-33: 143: 21.88
+	Hs
		1074107 ICEF1_HUMAN (15-424): 4.05e-53: 192: 15.55		CYH1_HUMAN (580-933): 1.33e-112: 365: 31.87
+	Hs
		1262771 ICEF1_HUMAN (15-424): 4.05e-53: 192: 15.55		CYH2_HUMAN (586-948): 4.93e-112: 363: 29.76
+	Hs
		212317 ICEF1_HUMAN (15-424): 4.05e-53: 192: 15.55		CYH3_HUMAN (587-933): 3.87e-111: 361: 31.09
+	Mm
		1194493 CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40		CYH1_MOUSE (587-933): 2.57e-113: 367: 32.21
+	Mm
		140106 CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40		CYH3_MOUSE (585-933): 1.38e-112: 365: 31.01
+	Hs
		1262772 ICEF1_HUMAN (15-424): 4.05e-53: 192: 15.55		CYH4_HUMAN (585-948): 2.3e-109: 356: 28.42
+	Mm
		926282 CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40		CYH2_MOUSE (586-948): 9.61e-112: 363: 29.49
+	Hs
		1074109 CNKR1_HUMAN (17-260): 6.93e-38: 153: 22.84		CYH1_HUMAN (580-933): 1.33e-112: 365: 31.87
+	Hs
		1281529 CNKR1_HUMAN (17-260): 6.93e-38: 153: 22.84		CYH2_HUMAN (586-948): 4.93e-112: 363: 29.76
+	Hs
		212319 CNKR1_HUMAN (17-260): 6.93e-38: 153: 22.84		CYH3_HUMAN (587-933): 3.87e-111: 361: 31.09
+	Hs
		299286 FARP2_HUMAN (5-183): 2.45e-30: 130: 21.69		PSD2_HUMAN (590-1094): 3.79e-114: 383: 15.52
+	Hs
		1281534 CNKR1_HUMAN (17-260): 6.93e-38: 153: 22.84		CYH4_HUMAN (585-948): 2.3e-109: 356: 28.42
+	Mm
		1194484 CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40		IQEC1_MOUSE (568-881): 3.87e-84: 300: 29.43
+	Dm
		1181488 Q7KNQ9_DROME (5-282): 1.28e-40: 163: 19.74		Q9V9Q6_DROME (578-879): 4.28e-97: 321: 33.33
+	Hs
		1266589 SWP70_HUMAN (55-446): 3.06e-44: 170: 11.36		GBF1_HUMAN (1280-1510): 1.07e-43: 177: 13.31