HitPredict

Interactor 1: IKZF5 (Q9H5V7)
Zinc finger protein Pegasus (Ikaros family zinc finger protein 5)
Gene: IKZF5

Interactor 2: IKZF3 (Q9UKT9)
Zinc finger protein Aiolos (Ikaros family zinc finger protein 3)
Gene: IKZF3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.698

Property	Details
Experiments	10978333, 28514442, 33961781, 25416956
Identification Methods	pull down, affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 419 Hs			1 509
+	Hs
		1332094 IKZF5_HUMAN (1-419): 0: 536: 100.00		IKZF2_HUMAN (4-504): 3.73e-144: 426: 46.98
+	Hs
		1033733 IKZF5_HUMAN (1-419): 0: 536: 100.00		IKZF1_HUMAN (31-505): 1.69e-140: 416: 55.51
+	Hs
		1329653 IKZF5_HUMAN (1-419): 0: 536: 100.00		IKZF4_HUMAN (110-505): 5.69e-135: 404: 50.35
+	Hs
		1332084 IKZF5_HUMAN (1-419): 0: 536: 100.00		IKZF5_HUMAN (111-504): 4.95e-87: 275: 23.62
+	Hs
		1033755 IKZF1_HUMAN (2-419): 1.43e-117: 354: 21.19		IKZF2_HUMAN (4-504): 3.73e-144: 426: 46.98
+	Hs
		1356563 IKZF3_HUMAN (69-417): 3.02e-114: 345: 24.22		IKZF2_HUMAN (4-504): 3.73e-144: 426: 46.98
+	Hs
		1033630 IKZF1_HUMAN (2-419): 1.43e-117: 354: 21.19		IKZF1_HUMAN (31-505): 1.69e-140: 416: 55.51
+	Hs
		1033731 IKZF1_HUMAN (2-419): 1.43e-117: 354: 21.19		IKZF4_HUMAN (110-505): 5.69e-135: 404: 50.35
+	Hs
		1033756 IKZF1_HUMAN (2-419): 1.43e-117: 354: 21.19		IKZF3_HUMAN (1-509): 2.04e-134: 400: 100.00
+	Hs
		1329658 IKZF3_HUMAN (69-417): 3.02e-114: 345: 24.22		IKZF4_HUMAN (110-505): 5.69e-135: 404: 50.35
+	Hs
		1356574 IKZF3_HUMAN (69-417): 3.02e-114: 345: 24.22		IKZF3_HUMAN (1-509): 2.04e-134: 400: 100.00
+	Hs
		1356562 IKZF2_HUMAN (10-419): 1.11e-99: 308: 23.19		IKZF2_HUMAN (4-504): 3.73e-144: 426: 46.98
+	Hs
		563270 ZN708_HUMAN (2-395): 4.41e-160: 464: 15.06		ZKSC8_HUMAN (40-276): 2.8e-64: 220: 22.36
+	Hs
		563279 ZNF7_HUMAN (7-416): 1.18e-178: 516: 16.43		ZNF16_HUMAN (342-508): 9.7e-36: 142: 10.24
+	Hs
		64162 ZN726_HUMAN (1-301): 5.97e-135: 402: 17.95		ZN430_HUMAN (3-219): 9.31e-63: 216: 24.89
+	Hs
		1055930 ZN235_HUMAN (2-249): 3.76e-104: 326: 18.29		ZN112_HUMAN (308-508): 5.03e-21: 99: 8.33