HitPredict

Interactor 1: ES8L2 (Q9H6S3)
Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2)
Gene: EPS8L2

Interactor 2: WASF3 (Q9UPY6)
Actin-binding protein WASF3 (Protein WAVE-3) (Verprolin homology domain-containing protein 3) (Wiskott-Aldrich syndrome protein family member 3) (WASP family protein member 3)
Gene: WASF3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 715 Hs			1 502
+	Hs
		1255839 ES8L1_HUMAN (19-713): 0: 653: 38.16		WASF2_HUMAN (1-484): 2.01e-57: 200: 43.60
+	Hs
		434114 LYN_HUMAN (431-709): 1.93e-62: 218: 13.64		WASF2_HUMAN (1-484): 2.01e-57: 200: 43.60
+	Hs
		203198 LCK_HUMAN (416-715): 1.35e-60: 213: 12.79		SYNJ1_HUMAN (11-499): 4.06e-38: 151: 11.82
+	Hs
		523092 SRC_HUMAN (425-709): 1.22e-68: 236: 14.04		CBP_HUMAN (153-498): 1.18e-22: 104: 13.84
+	Hs
		209188 NCK2_HUMAN (492-556): 5.48e-20: 94.5: 30.77		WASF3_HUMAN (1-502): 1.19e-73: 243: 100.00
+	Hs
		442866 HCK_HUMAN (430-715): 6.22e-66: 228: 13.09		CBP_HUMAN (153-498): 1.18e-22: 104: 13.84
+	Hs
		276974 STAM2_HUMAN (337-607): 1.59e-54: 197: 18.75		SC31A_HUMAN (94-467): 1.6e-32: 134: 13.88
+	Ce
		99434 SRC2_CAEEL (431-681): 8.88e-59: 208: 15.50		F5GUF0_CAEEL (277-502): 5.01e-30: 118: 29.34
+	Hs
		433930 LYN_HUMAN (431-709): 1.93e-62: 218: 13.64		CBP_HUMAN (153-498): 1.18e-22: 104: 13.84
+	Hs
		522749 SRC_HUMAN (425-709): 1.22e-68: 236: 14.04		MUC1_HUMAN (77-452): 1.55e-13: 75.5: 11.00
+	Hs
		297808 LYN_HUMAN (431-709): 1.93e-62: 218: 13.64		K0754_HUMAN (152-485): 3.43e-17: 87.4: 11.55
+	Hs
		209133 NCK2_HUMAN (492-556): 5.48e-20: 94.5: 30.77		WASF1_HUMAN (1-500): 3.42e-59: 206: 43.57
+	Hs
		209196 NCK2_HUMAN (492-556): 5.48e-20: 94.5: 30.77		WASF2_HUMAN (1-484): 2.01e-57: 200: 43.60
+	Hs
		433560 LYN_HUMAN (431-709): 1.93e-62: 218: 13.64		MUC1_HUMAN (77-452): 1.55e-13: 75.5: 11.00
+	Hs
		557755 NCK1_HUMAN (492-556): 3.45e-16: 83: 27.69		WASF1_HUMAN (1-500): 3.42e-59: 206: 43.57
+	Hs
		411582 LCK_HUMAN (416-715): 1.35e-60: 213: 12.79		MUC1_HUMAN (77-452): 1.55e-13: 75.5: 11.00
+	Hs
		557843 NCK1_HUMAN (492-556): 3.45e-16: 83: 27.69		WASF2_HUMAN (1-484): 2.01e-57: 200: 43.60
+	Hs
		203208 NCK1_HUMAN (492-556): 3.45e-16: 83: 27.69		SYNJ1_HUMAN (11-499): 4.06e-38: 151: 11.82
+	Ce
		712432 Q95PW9_CAEEL (493-714): 3.13e-24: 107: 14.80		SC161_CAEEL (146-431): 6.97e-21: 98.6: 12.46