HitPredict

Interactor 1: PEAK1 (Q9H792)
Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)
Gene: PEAK1

Interactor 2: SH22A (Q9NP31)
SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein)
Gene: SH2D2A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1746 Hs			1 389
+	Hs
		434012 PEAK1_HUMAN (1-1746): 0: 2185: 100.00		LYN_HUMAN (9-313): 7.12e-48: 171: 14.82
+	Hs
		802905 PEAK1_HUMAN (1-1746): 0: 2185: 100.00		CRKL_HUMAN (95-347): 5.6e-49: 169: 21.76
+	Hs
		924867 PEAK1_HUMAN (1-1746): 0: 2185: 100.00		GRB2_HUMAN (56-256): 4.42e-50: 169: 15.71
+	Hs
		411858 PEAK1_HUMAN (1-1746): 0: 2185: 100.00		LCK_HUMAN (22-210): 4.42e-45: 164: 17.31
+	Hs
		802730 PEAK1_HUMAN (1-1746): 0: 2185: 100.00		CRK_HUMAN (95-341): 6.51e-46: 161: 17.28
+	Mm
		1141136 PEAK1_MOUSE (1-1746): 0: 2159: 85.76		GRB2_MOUSE (56-256): 2.26e-50: 170: 15.71
+	Mm
		403411 KPCE_MOUSE (1352-1719): 4.36e-92: 318: 13.12		SRC_MOUSE (4-280): 1.66e-51: 182: 17.73
+	Hs
		522810 AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07		SRC_HUMAN (21-280): 1.14e-48: 174: 17.73
+	Mm
		411915 KPCE_MOUSE (1352-1719): 4.36e-92: 318: 13.12		LCK_MOUSE (50-210): 2.53e-44: 162: 20.00
+	Hs
		412046 AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07		FYN_HUMAN (38-280): 1.65e-45: 165: 15.67
+	Hs
		411994 KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30		FYN_HUMAN (38-280): 1.65e-45: 165: 15.67
+	Hs
		568579 KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30		CRK_HUMAN (95-341): 6.51e-46: 161: 17.28
+	Hs
		681838 AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07		PTK6_HUMAN (84-194): 4.58e-32: 127: 28.93
+	Hs
		1295741 PINK1_HUMAN (1357-1669): 2.87e-73: 258: 23.64		HSH2D_HUMAN (76-257): 5.81e-43: 154: 31.32
+	Hs
		522780 KS6B1_HUMAN (1453-1683): 8.42e-45: 173: 16.17		SRC_HUMAN (21-280): 1.14e-48: 174: 17.73
+	Hs
		883142 HUNK_HUMAN (1405-1659): 1.25e-44: 176: 20.61		GRB2_HUMAN (56-256): 4.42e-50: 169: 15.71
+	Hs
		433578 KS6B1_HUMAN (1453-1683): 8.42e-45: 173: 16.17		LYN_HUMAN (9-313): 7.12e-48: 171: 14.82
+	Mm
		1123037 PRAG1_MOUSE (1-91): 5.76e-34: 145: 38.04		CRK_MOUSE (95-341): 3.68e-46: 162: 17.65
+	Hs
		802632 PEAK3_HUMAN (1653-1743): 1.22e-30: 129: 38.46		CRK_HUMAN (95-341): 6.51e-46: 161: 17.28
+	Hs
		616681 KS6B1_HUMAN (1453-1683): 8.42e-45: 173: 16.17		KSYK_HUMAN (94-213): 1.09e-17: 86.9: 23.81