HitPredict

Interactor 1: AGO3 (Q9H9G7)
Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3)
Gene: AGO3

Interactor 2: TNR6C (Q9HCJ0)
Trinucleotide repeat-containing gene 6C protein
Gene: TNRC6C

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.696

Property	Details
Experiments	19470757, 19383768, 24778252, 29395067
Identification Methods	affinity chromatography technology, pull down, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000932 - P-body GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0035278 - miRNA-mediated gene silencing by inhibition of translation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 860 Hs			1 1936
+	Hs
		1336210 AGO1_HUMAN (9-860): 0: 1150: 84.62		TNR6C_HUMAN (24-1936): 0: 762: 100.00
+	Hs
		1336208 AGO2_HUMAN (15-860): 0: 1142: 80.73		TNR6C_HUMAN (24-1936): 0: 762: 100.00
+	Hs
		1336198 AGO4_HUMAN (3-860): 0: 1118: 80.81		TNR6C_HUMAN (24-1936): 0: 762: 100.00
+	Mm
		1112540 AGO2_MOUSE (3-860): 0: 1144: 79.56		TNR6C_MOUSE (211-1936): 0: 626: 88.47
+	Hs
		1242656 AGO3_HUMAN (1-860): 0: 1182: 100.00		TNR6A_HUMAN (2-1933): 2.2e-125: 440: 35.43
+	Hs
		1334290 AGO3_HUMAN (1-860): 0: 1182: 100.00		TNR6B_HUMAN (18-1920): 9.22e-118: 415: 30.70
+	Hs
		1242692 AGO1_HUMAN (9-860): 0: 1150: 84.62		TNR6A_HUMAN (2-1933): 2.2e-125: 440: 35.43
+	Hs
		1242690 AGO2_HUMAN (15-860): 0: 1142: 80.73		TNR6A_HUMAN (2-1933): 2.2e-125: 440: 35.43
+	Hs
		1356716 AGO1_HUMAN (9-860): 0: 1150: 84.62		TNR6B_HUMAN (18-1920): 9.22e-118: 415: 30.70
+	Hs
		1242663 AGO4_HUMAN (3-860): 0: 1118: 80.81		TNR6A_HUMAN (2-1933): 2.2e-125: 440: 35.43
+	Hs
		1356626 AGO2_HUMAN (15-860): 0: 1142: 80.73		TNR6B_HUMAN (18-1920): 9.22e-118: 415: 30.70
+	Hs
		1336289 AGO4_HUMAN (3-860): 0: 1118: 80.81		TNR6B_HUMAN (18-1920): 9.22e-118: 415: 30.70
+	Mm
		1112703 AGO2_MOUSE (3-860): 0: 1144: 79.56		TNR6A_MOUSE (23-1933): 4.13e-108: 386: 32.98
+	Hs
		257701 AGO3_HUMAN (1-860): 0: 1182: 100.00		ANR17_HUMAN (984-1742): 1.35e-50: 200: 15.11
+	Mm
		1206838 AGO2_MOUSE (3-860): 0: 1144: 79.56		TNR6B_MOUSE (247-1920): 3.57e-60: 231: 21.34
+	Dm
		1103823 Q32KD4_DROME (1-860): 0: 1102: 70.89		GAWKY_DROME (650-1849): 7.88e-73: 271: 21.24
+	Dm
		1182892 Q7KY08_DROME (1-860): 0: 1100: 70.89		GAWKY_DROME (650-1849): 7.88e-73: 271: 21.24
+	Hs
		257722 AGO1_HUMAN (9-860): 0: 1150: 84.62		ANR17_HUMAN (984-1742): 1.35e-50: 200: 15.11
+	Hs
		257720 AGO2_HUMAN (15-860): 0: 1142: 80.73		ANR17_HUMAN (984-1742): 1.35e-50: 200: 15.11
+	At
		98377 AGO4_ARATH (13-859): 0: 858: 30.84		RDM3_ARATH (165-1130): 1.22e-66: 252: 15.07