HitPredict

Interactor 1: AGO3 (Q9H9G7)
Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3)
Gene: AGO3

Interactor 2: AGO4 (Q9HCK5)
Protein argonaute-4 (Argonaute4) (hAgo4) (Argonaute RISC catalytic component 4) (Eukaryotic translation initiation factor 2C 4) (eIF-2C 4) (eIF2C 4)
Gene: AGO4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.861

The method score is based on:

Property Details
Experiments 33961781, 19167051, 24778252
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains ArgoL1~ArgoL1, ArgoL1~ArgoL2, ArgoL1~ArgoN, ArgoL1~PAZ, ArgoL1~Piwi, ArgoL2~ArgoMid, ArgoL2~ArgoN, ArgoL2~PAZ, ArgoL2~Piwi, ArgoMid~ArgoMid, ArgoMid~Piwi, ArgoN~Piwi, PAZ~PAZ, PAZ~Piwi, Piwi~Piwi
Common GO terms GO:0000932 - P-body
GO:0003725 - double-stranded RNA binding
GO:0003727 - single-stranded RNA binding
GO:0004521 - RNA endonuclease activity
GO:0005634 - nucleus
and 14 others

more...
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 860
Hs

1 861
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Zm
+ Mm
+ Dr
+ Dm
+ Dm

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Last updated: 15 Jul 2024