HitPredict

Interactor 1: AGO3 (Q9H9G7)
Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3)
Gene: AGO3

Interactor 2: TNR6B (Q9UPQ9)
Trinucleotide repeat-containing gene 6B protein
Gene: TNRC6B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.748

Property	Details
Experiments	26496610, 19167051, 19470757, 19383768, 24778252, 29395067, 24043833
Identification Methods	affinity chromatography technology, pull down, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000932 - P-body GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0035278 - miRNA-mediated gene silencing by inhibition of translation
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 860 Hs			1 1833
+	Hs
		1356716 AGO1_HUMAN (9-860): 0: 1150: 84.62		TNR6B_HUMAN (28-1833): 0: 1086: 100.00
+	Hs
		1356626 AGO2_HUMAN (15-860): 0: 1142: 80.73		TNR6B_HUMAN (28-1833): 0: 1086: 100.00
+	Hs
		1336289 AGO4_HUMAN (3-860): 0: 1118: 80.81		TNR6B_HUMAN (28-1833): 0: 1086: 100.00
+	Mm
		1206838 AGO2_MOUSE (3-860): 0: 1144: 79.56		TNR6B_MOUSE (28-1833): 0: 1014: 91.06
+	Hs
		1242656 AGO3_HUMAN (1-860): 0: 1182: 100.00		TNR6A_HUMAN (2-1833): 0: 785: 35.34
+	Hs
		1242692 AGO1_HUMAN (9-860): 0: 1150: 84.62		TNR6A_HUMAN (2-1833): 0: 785: 35.34
+	Hs
		1242690 AGO2_HUMAN (15-860): 0: 1142: 80.73		TNR6A_HUMAN (2-1833): 0: 785: 35.34
+	Hs
		1242663 AGO4_HUMAN (3-860): 0: 1118: 80.81		TNR6A_HUMAN (2-1833): 0: 785: 35.34
+	Mm
		1112703 AGO2_MOUSE (3-860): 0: 1144: 79.56		TNR6A_MOUSE (2-1833): 0: 732: 33.84
+	Hs
		1334274 AGO3_HUMAN (1-860): 0: 1182: 100.00		TNR6C_HUMAN (34-1830): 0: 655: 34.21
+	Hs
		1336210 AGO1_HUMAN (9-860): 0: 1150: 84.62		TNR6C_HUMAN (34-1830): 0: 655: 34.21
+	Hs
		1336208 AGO2_HUMAN (15-860): 0: 1142: 80.73		TNR6C_HUMAN (34-1830): 0: 655: 34.21
+	Hs
		1336198 AGO4_HUMAN (3-860): 0: 1118: 80.81		TNR6C_HUMAN (34-1830): 0: 655: 34.21
+	Mm
		1112540 AGO2_MOUSE (3-860): 0: 1144: 79.56		TNR6C_MOUSE (234-1830): 3.01e-177: 584: 33.00
+	Dm
		1103823 Q32KD4_DROME (1-860): 0: 1102: 70.89		GAWKY_DROME (615-1735): 3.49e-145: 488: 21.36
+	Dm
		1182892 Q7KY08_DROME (1-860): 0: 1100: 70.89		GAWKY_DROME (615-1735): 3.49e-145: 488: 21.36
+	At
		98377 AGO4_ARATH (13-859): 0: 858: 30.84		RDM3_ARATH (47-806): 1.64e-18: 94.9: 13.29
+	At
		1125379 AGO4_ARATH (13-859): 0: 858: 30.84		NRPE1_ARATH (54-556): 1.7e-15: 85.3: 10.53