HitPredict

Interactor 1: AGO3 (Q9H9G7)
Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3)
Gene: AGO3

Interactor 2: DICER (Q9UPY3)
Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI)
Gene: DICER1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.71 1.00 0.847

The method score is based on:

Property Details
Experiments 26496610, 24778252, 12906857
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains ArgoL1~PAZ, ArgoL2~PAZ, PAZ~PAZ, PAZ~Ribonuclease_3, PAZ~Piwi
Common GO terms GO:0003723 - RNA binding
GO:0003725 - double-stranded RNA binding
GO:0004521 - RNA endonuclease activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
and 7 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 860
Hs

1 1922
+ Mm
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Ce
+ Ce
+ Hs
+ Hs
+ Hs
+ Ce
+ Hs
+ Hs
+ Hs
+ Ce
+ Ce
+ Ce
+ Dm
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024