HitPredict

Interactor 1: MLXIP (Q9HAP2)
MLX-interacting protein (Class E basic helix-loop-helix protein 36) (bHLHe36) (Transcriptional activator MondoA)
Gene: MLXIP

Interactor 2: MLX (Q9UH92)
Max-like protein X (Class D basic helix-loop-helix protein 13) (bHLHd13) (Max-like bHLHZip protein) (Protein BigMax) (Transcription factor-like protein 4)
Gene: MLX

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 1.00 0.933

The method score is based on:

Property Details
Experiments 20027290, 11073985, 12446771, 28514442, 33961781
Identification Methods pull down, far western blotting, two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains HLH~HLH
Common GO terms GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0005634 - nucleus
and 2 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 919
Hs

1 298
+ Mm
+ Hs
+ Hs
+ Ce
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024