HitPredict

Interactor 1: PELI2 (Q9HAT8)
E3 ubiquitin-protein ligase pellino homolog 2 (Pellino-2) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase pellino homolog 2)
Gene: PELI2

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	25027698, 36776133, 12804775
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005829 - cytosol GO:0034450 - ubiquitin-ubiquitin ligase activity GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 420 Hs			1 522
+	Hs
		1291030 PELI1_HUMAN (1-420): 0: 796: 81.43		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		1231628 PELI3_HUMAN (3-420): 0: 698: 67.27		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		1163038 PELI2_HUMAN (1-420): 0: 826: 100.00		TRAF7_HUMAN (60-208): 5.13e-18: 89.5: 23.26