HitPredict

Interactor 1: SMUF2 (Q9HAU4)
E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)
Gene: SMURF2

Interactor 2: SMUF2 (Q9HAU4)
E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)
Gene: SMURF2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.986

The method score is based on:

Property Details
Experiments 17996703, 17719543, 25438670, 26949039, 28611047, 28292929, 27086113, 29463679, 29964046, 30021006, 30587574, 31628949, 33430646, 20858899, 16061177, 15231748, 23973329
Identification Methods enzymatic study, two hybrid, affinity chromatography technology, nuclear magnetic resonance, pull down
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains C2~C2, HECT~HECT, HECT~WW, WW~WW
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
and 18 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 748
Hs

1 748
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Last updated: 15 Jul 2024