HitPredict

Interactor 1: SMUF2 (Q9HAU4)
E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)
Gene: SMURF2

Interactor 2: CUED1 (Q9NWM3)
CUE domain-containing protein 1
Gene: CUEDC1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.50	0.607

Property	Details
Experiments	33099540, 33961781, 15231748
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 748 Hs			1 386
+	Hs
		1336093 SMUF1_HUMAN (1-748): 0: 748: 70.44		CUED1_HUMAN (1-386): 0: 606: 100.00
+	Hs
		808293 NEDD4_HUMAN (104-746): 0: 628: 38.73		CUED1_HUMAN (1-386): 0: 606: 100.00
+	Hs
		1299649 NED4L_HUMAN (5-396): 1.96e-36: 149: 18.58		CUED1_HUMAN (1-386): 0: 606: 100.00
+	Hs
		1294873 ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44		CUED1_HUMAN (1-386): 0: 606: 100.00
+	Hs
		1327924 WWP1_HUMAN (2-395): 4.38e-20: 97.5: 15.47		CUED1_HUMAN (1-386): 0: 606: 100.00
+	Hs
		1347233 HECW2_HUMAN (19-281): 8.01e-17: 87.5: 14.80		CUED1_HUMAN (1-386): 0: 606: 100.00