HitPredict

Interactor 1: SMUF2 (Q9HAU4)
E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)
Gene: SMURF2

Interactor 2: RNF11 (Q9Y3C5)
RING finger protein 11
Gene: RNF11

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.740

Property	Details
Experiments	28292929, 15231748, 31985874, 14562029, 20676133, 14755250
Identification Methods	affinity chromatography technology, enzymatic study, two hybrid, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0005634 - nucleus GO:0006511 - ubiquitin-dependent protein catabolic process GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 748 Hs			1 154
+	Hs
		1334874 SMUF2_HUMAN (1-748): 0: 834: 100.00		RNF12_HUMAN (91-146): 1.14e-21: 91.8: 39.29
+	Hs
		1336128 SMUF1_HUMAN (1-748): 0: 748: 70.44		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Mm
		808380 NEDD4_MOUSE (14-746): 0: 692: 34.57		RNF11_MOUSE (1-154): 1.27e-42: 140: 99.35
+	Mm
		1208051 ITCH_MOUSE (3-748): 0: 659: 32.95		RNF11_MOUSE (1-154): 1.27e-42: 140: 99.35
+	Hs
		808333 NEDD4_HUMAN (104-746): 0: 628: 38.73		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		1192280 HUWE1_HUMAN (114-747): 0: 589: 31.46		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		1299666 NED4L_HUMAN (5-396): 1.96e-36: 149: 18.58		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		125810 WWP2_HUMAN (1-416): 7.64e-26: 116: 17.39		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		1255980 NED4L_HUMAN (5-396): 1.96e-36: 149: 18.58		RN128_HUMAN (57-153): 7.46e-25: 100: 25.77
+	Hs
		1294890 ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		1327938 WWP1_HUMAN (2-395): 4.38e-20: 97.5: 15.47		RNF11_HUMAN (1-154): 1.51e-42: 140: 100.00
+	Hs
		125596 WWP2_HUMAN (1-416): 7.64e-26: 116: 17.39		RN128_HUMAN (57-153): 7.46e-25: 100: 25.77
+	Hs
		1240725 ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44		RN149_HUMAN (54-147): 1.09e-25: 102: 34.04
+	Hs
		1255979 ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44		RN128_HUMAN (57-153): 7.46e-25: 100: 25.77