HitPredict

Interactor 1: CLSPN (Q9HAW4)
Claspin (hClaspin)
Gene: CLSPN

Interactor 2: FZR1 (Q9UM11)
Fizzy-related protein homolog (Fzr) (CDC20-like protein 1) (Cdh1/Hct1 homolog) (hCDH1)
Gene: FZR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	33306668, 19477924, 18662541
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair GO:0007095 - mitotic G2 DNA damage checkpoint signaling GO:0010997 - anaphase-promoting complex binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1339 Hs			1 496
+	Hs
		1334998 CLSPN_HUMAN (1-1339): 0: 682: 100.00		NLE1_HUMAN (52-385): 3.28e-60: 207: 16.32
+	Hs
		903529 CLSPN_HUMAN (1-1339): 0: 682: 100.00		WDR5_HUMAN (389-496): 1.49e-26: 111: 18.35
+	Hs
		1017442 CLSPN_HUMAN (1-1339): 0: 682: 100.00		CDC20_HUMAN (395-494): 7.34e-10: 63: 16.67
+	Sp
		252177 MDN1_SCHPO (141-741): 2.33e-19: 97.5: 13.25		NLE1_SCHPO (18-471): 3.57e-89: 283: 17.32
+	Hs
		1345855 MDN1_HUMAN (31-746): 1.29e-18: 94.8: 13.58		NLE1_HUMAN (52-385): 3.28e-60: 207: 16.32
+	Hs
		1264784 TITIN_HUMAN (38-1005): 1.86e-09: 65: 8.69		SNR40_HUMAN (32-339): 1.33e-49: 175: 15.89
+	Hs
		1264822 TITIN_HUMAN (38-1005): 1.86e-09: 65: 8.69		FZR1_HUMAN (319-495): 6.65e-25: 109: 18.68