HitPredict

Interactor 1: RC3H2 (Q9HBD1)
Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2)
Gene: RC3H2

Interactor 2: IF2B1 (Q9NZI8)
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (IMP1) (Coding region determinant-binding protein) (CRD-BP) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zipcode-binding protein 1) (ZBP-1)
Gene: IGF2BP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30209976, 23663784
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~zf-CCCH
Common GO terms	GO:0000932 - P-body GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0010494 - cytoplasmic stress granule
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1191 Hs			1 577
+	Hs
		128307 RC3H2_HUMAN (1-1191): 0: 1105: 100.00		IF2B3_HUMAN (1-577): 4.61e-149: 443: 71.85
+	Hs
		1072185 RC3H2_HUMAN (1-1191): 0: 1105: 100.00		PCBP2_HUMAN (407-575): 6.35e-44: 162: 27.43
+	Hs
		128201 RC3H1_HUMAN (1-1108): 0: 788: 49.30		IF2B3_HUMAN (1-577): 4.61e-149: 443: 71.85
+	Hs
		1136332 RC3H1_HUMAN (1-1108): 0: 788: 49.30		IF2B1_HUMAN (1-577): 4.69e-147: 437: 100.00
+	Hs
		1335270 RC3H2_HUMAN (1-1191): 0: 1105: 100.00		IF2B2_HUMAN (79-477): 2.19e-19: 93.9: 14.84
+	Hs
		1294257 RC3H2_HUMAN (1-1191): 0: 1105: 100.00		FUBP3_HUMAN (190-413): 5.36e-18: 89.3: 18.25
+	Hs
		1072026 RC3H2_HUMAN (1-1191): 0: 1105: 100.00		PCBP1_HUMAN (476-574): 1.53e-12: 71: 17.17
+	Hs
		1072106 RC3H1_HUMAN (1-1108): 0: 788: 49.30		PCBP2_HUMAN (407-575): 6.35e-44: 162: 27.43
+	Hs
		1136386 RC3H1_HUMAN (1-1108): 0: 788: 49.30		IF2B2_HUMAN (79-477): 2.19e-19: 93.9: 14.84
+	Hs
		1136232 RC3H1_HUMAN (1-1108): 0: 788: 49.30		FUBP3_HUMAN (190-413): 5.36e-18: 89.3: 18.25
+	Hs
		1071900 RC3H1_HUMAN (1-1108): 0: 788: 49.30		PCBP1_HUMAN (476-574): 1.53e-12: 71: 17.17
+	Hs
		325916 LATS1_HUMAN (518-1066): 1.1e-09: 65: 11.05		IF2B1_HUMAN (1-577): 4.69e-147: 437: 100.00
+	Hs
		257683 ANR17_HUMAN (335-957): 1.44e-12: 74.7: 8.44		FUBP3_HUMAN (190-413): 5.36e-18: 89.3: 18.25
+	Hs
		1056922 MDC1_HUMAN (442-806): 1.14e-11: 71.8: 12.21		FUBP1_HUMAN (118-353): 1.13e-15: 82.3: 14.01
+	Hs
		1056915 MDC1_HUMAN (442-806): 1.14e-11: 71.8: 12.21		FUBP2_HUMAN (118-416): 2.4e-14: 78.1: 15.89