HitPredict

Interactor 1: RC3H2 (Q9HBD1)
Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2)
Gene: RC3H2

Interactor 2: IF2B2 (Q9Y6M1)
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62) (IGF-II mRNA-binding protein 2) (VICKZ family member 2)
Gene: IGF2BP2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30209976, 23663784
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~zf-CCCH
Common GO terms	GO:0000932 - P-body GO:0003723 - RNA binding GO:0010494 - cytoplasmic stress granule
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1191 Hs			1 599
+	Hs
		128307 RC3H2_HUMAN (1-1191): 0: 1105: 100.00		IF2B3_HUMAN (2-599): 4.89e-134: 405: 62.36
+	Hs
		1335208 RC3H2_HUMAN (1-1191): 0: 1105: 100.00		IF2B1_HUMAN (2-599): 2.29e-130: 395: 63.89
+	Hs
		1072185 RC3H2_HUMAN (1-1191): 0: 1105: 100.00		PCBP2_HUMAN (422-597): 7.25e-36: 140: 26.92
+	Hs
		1136386 RC3H1_HUMAN (1-1108): 0: 788: 49.30		IF2B2_HUMAN (1-599): 1.06e-146: 438: 100.00
+	Hs
		1294257 RC3H2_HUMAN (1-1191): 0: 1105: 100.00		FUBP3_HUMAN (196-414): 3.06e-18: 90.2: 15.51
+	Hs
		128201 RC3H1_HUMAN (1-1108): 0: 788: 49.30		IF2B3_HUMAN (2-599): 4.89e-134: 405: 62.36
+	Hs
		1136332 RC3H1_HUMAN (1-1108): 0: 788: 49.30		IF2B1_HUMAN (2-599): 2.29e-130: 395: 63.89
+	Hs
		1072026 RC3H2_HUMAN (1-1191): 0: 1105: 100.00		PCBP1_HUMAN (422-530): 8.21e-11: 65.8: 25.69
+	Hs
		1072106 RC3H1_HUMAN (1-1108): 0: 788: 49.30		PCBP2_HUMAN (422-597): 7.25e-36: 140: 26.92
+	Hs
		1136232 RC3H1_HUMAN (1-1108): 0: 788: 49.30		FUBP3_HUMAN (196-414): 3.06e-18: 90.2: 15.51
+	Hs
		903980 RC3H1_HUMAN (1-1108): 0: 788: 49.30		HNRPK_HUMAN (386-596): 5.84e-18: 88.9: 17.09
+	Hs
		1071900 RC3H1_HUMAN (1-1108): 0: 788: 49.30		PCBP1_HUMAN (422-530): 8.21e-11: 65.8: 25.69
+	Hs
		325916 LATS1_HUMAN (518-1066): 1.1e-09: 65: 11.05		IF2B1_HUMAN (2-599): 2.29e-130: 395: 63.89
+	Hs
		257683 ANR17_HUMAN (335-957): 1.44e-12: 74.7: 8.44		FUBP3_HUMAN (196-414): 3.06e-18: 90.2: 15.51
+	Hs
		959734 CHD7_HUMAN (491-1004): 4.82e-13: 76.2: 7.21		VIGLN_HUMAN (444-585): 4.33e-12: 71.5: 19.01
+	Hs
		1056915 MDC1_HUMAN (442-806): 1.14e-11: 71.8: 12.21		FUBP2_HUMAN (414-584): 1.07e-10: 66.6: 28.73
+	Hs
		867090 SC24C_HUMAN (362-642): 1.58e-09: 64.6: 12.98		VIGLN_HUMAN (444-585): 4.33e-12: 71.5: 19.01