HitPredict

Interactor 1: CBX8 (Q9HC52)
Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1)
Gene: CBX8

Interactor 2: SCML2 (Q9UQR0)
Sex comb on midleg-like protein 2
Gene: SCML2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0031519 - PcG protein complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 389 Hs			1 700
+	Hs
		316204 CBX6_HUMAN (1-386): 1.08e-65: 216: 33.26		SCML2_HUMAN (1-700): 0: 777: 100.00
+	Hs
		123346 CBX4_HUMAN (1-349): 3.84e-62: 210: 21.93		SCML2_HUMAN (1-700): 0: 777: 100.00
+	Hs
		1220894 CBX8_HUMAN (1-389): 5.01e-104: 314: 100.00		PHC2_HUMAN (211-697): 1.07e-85: 289: 15.99
+	Hs
		316088 CBX6_HUMAN (1-386): 1.08e-65: 216: 33.26		PHC2_HUMAN (211-697): 1.07e-85: 289: 15.99
+	Hs
		123280 CBX4_HUMAN (1-349): 3.84e-62: 210: 21.93		PHC2_HUMAN (211-697): 1.07e-85: 289: 15.99
+	Hs
		943094 CBX8_HUMAN (1-389): 5.01e-104: 314: 100.00		PHC1_HUMAN (455-696): 4.09e-47: 181: 21.57
+	Hs
		1242737 CBX8_HUMAN (1-389): 5.01e-104: 314: 100.00		PHC3_HUMAN (445-697): 4.59e-41: 163: 20.30
+	Hs
		1335791 CBX8_HUMAN (1-389): 5.01e-104: 314: 100.00		SCML1_HUMAN (471-698): 6.13e-32: 128: 29.54
+	Dr
		1193375 Q804D1_DANRE (1-249): 1.15e-47: 170: 26.91		PHC2_DANRE (253-697): 2.86e-78: 269: 17.04
+	Hs
		1292155 CBX8_HUMAN (1-389): 5.01e-104: 314: 100.00		SCMH1_HUMAN (7-131): 9.67e-23: 105: 32.03
+	Hs
		69543 B0QXZ6_HUMAN (1-386): 6.53e-68: 221: 34.48		PHC1_HUMAN (455-696): 4.09e-47: 181: 21.57
+	Hs
		316005 CBX6_HUMAN (1-386): 1.08e-65: 216: 33.26		PHC1_HUMAN (455-696): 4.09e-47: 181: 21.57
+	Hs
		123234 CBX4_HUMAN (1-349): 3.84e-62: 210: 21.93		PHC1_HUMAN (455-696): 4.09e-47: 181: 21.57
+	Hs
		316103 CBX6_HUMAN (1-386): 1.08e-65: 216: 33.26		PHC3_HUMAN (445-697): 4.59e-41: 163: 20.30
+	Hs
		123290 CBX4_HUMAN (1-349): 3.84e-62: 210: 21.93		PHC3_HUMAN (445-697): 4.59e-41: 163: 20.30
+	Mm
		675498 CBX2_MOUSE (2-335): 3.31e-46: 167: 21.11		PHC1_MOUSE (220-696): 2.89e-48: 185: 13.94
+	Hs
		316200 CBX6_HUMAN (1-386): 1.08e-65: 216: 33.26		SCML1_HUMAN (471-698): 6.13e-32: 128: 29.54
+	Hs
		123342 CBX4_HUMAN (1-349): 3.84e-62: 210: 21.93		SCML1_HUMAN (471-698): 6.13e-32: 128: 29.54
+	Hs
		316124 CBX6_HUMAN (1-386): 1.08e-65: 216: 33.26		SCMH1_HUMAN (7-131): 9.67e-23: 105: 32.03
+	Hs
		123303 CBX4_HUMAN (1-349): 3.84e-62: 210: 21.93		SCMH1_HUMAN (7-131): 9.67e-23: 105: 32.03