HitPredict

Interactor 1: SMUF1 (Q9HCE7)
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Gene: SMURF1

Interactor 2: SMUF1 (Q9HCE7)
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Gene: SMURF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.981

The method score is based on:

Property Details
Experiments 17996703, 18641638, 22152476, 26949039, 28169289, 28063214, 30587574, 31628949, 34662580, 19318350, 22921829, 22496338, 24821572
Identification Methods enzymatic study, affinity chromatography technology, pull down, x-ray crystallography
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains C2~C2, HECT~HECT, HECT~WW, WW~WW
Common GO terms GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005160 - transforming growth factor beta receptor binding
GO:0005543 - phospholipid binding
GO:0005654 - nucleoplasm
and 30 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

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Hs

1 757
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024