HitPredict

Interactor 1: SMUF1 (Q9HCE7)
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Gene: SMURF1

Interactor 2: PDLI7 (Q9NR12)
PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma)
Gene: PDLIM7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	16611643, 17510966
Identification Methods	affinity chromatography technology, unspecified method, x-ray crystallography, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0030154 - cell differentiation
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 757 Hs			1 457
+	Hs
		125735 WWP2_HUMAN (97-757): 0: 708: 36.69		PDLI7_HUMAN (1-457): 2.02e-91: 286: 100.00
+	Hs
		816282 SMUF1_HUMAN (1-757): 0: 891: 100.00		LIMS1_HUMAN (298-452): 6.05e-14: 74.3: 24.54
+	Hs
		808283 NEDD4_HUMAN (93-755): 0: 673: 36.63		PDLI7_HUMAN (1-457): 2.02e-91: 286: 100.00
+	Mm
		1143674 ITCH_MOUSE (1-757): 0: 763: 33.03		TGFI1_MOUSE (43-397): 5.17e-34: 134: 16.62
+	Hs
		200183 ITCH_HUMAN (1-757): 0: 733: 31.28		TGFI1_HUMAN (71-397): 1.78e-33: 133: 17.43
+	Hs
		200165 NEDD4_HUMAN (93-755): 0: 673: 36.63		TGFI1_HUMAN (71-397): 1.78e-33: 133: 17.43
+	Hs
		1327916 WWP1_HUMAN (2-395): 1.65e-27: 121: 14.94		PDLI7_HUMAN (1-457): 2.02e-91: 286: 100.00
+	Hs
		1059444 WWP1_HUMAN (2-395): 1.65e-27: 121: 14.94		ZN846_HUMAN (61-424): 9.09e-54: 190: 9.73
+	Hs
		200184 NED4L_HUMAN (6-396): 7.88e-36: 147: 16.88		TGFI1_HUMAN (71-397): 1.78e-33: 133: 17.43