HitPredict

Interactor 1: GPN1 (Q9HCN4)
GPN-loop GTPase 1 (EC 3.6.5.-) (MBD2-interacting protein) (MBDin) (RNAPII-associated protein 4) (XPA-binding protein 1)
Gene: GPN1

Interactor 2: GPN3 (Q9UHW5)
GPN-loop GTPase 3 (ATP-binding domain 1 family member C)
Gene: GPN3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.960

Property	Details
Experiments	26186194, 28514442, 33961781, 24981860, 32985767, 17643375, 25241168
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	ATP_bind_1~ATP_bind_1
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 374 Hs			1 284
+	Hs
		1334507 GPN1_HUMAN (1-374): 0: 529: 100.00		GPN2_HUMAN (4-254): 1.73e-132: 379: 42.13
+	Sc
		812021 GPN1_YEAST (22-370): 4.42e-152: 435: 50.41		GPN3_YEAST (1-268): 5.79e-122: 351: 43.17
+	Sc
		812026 GPN1_YEAST (22-370): 4.42e-152: 435: 50.41		GPN2_YEAST (3-254): 8.37e-105: 310: 34.35
+	Ce
		804442 GPN1_CAEEL (2-283): 3.83e-133: 386: 57.90		Q9XW68_CAEEL (3-272): 3.78e-124: 356: 52.21
+	Dm
		1359121 Q9V3R3_DROME (1-374): 1.81e-130: 380: 46.88		Q9VI70_DROME (3-269): 7.9e-123: 353: 52.48
+	At
		1122850 QQT2_ARATH (7-335): 1.12e-138: 401: 53.29		QQT1_ARATH (4-254): 8.77e-112: 326: 41.02
+	Ce
		136322 GPN1_CAEEL (2-283): 3.83e-133: 386: 57.90		O01426_CAEEL (4-264): 2.55e-111: 324: 35.88
+	Sc
		811996 GPN1_YEAST (22-370): 4.42e-152: 435: 50.41		GPN1_YEAST (1-284): 1.16e-86: 265: 22.34
+	Dm
		1359123 Q9V3R3_DROME (1-374): 1.81e-130: 380: 46.88		Q9VU67_DROME (2-254): 4.09e-108: 317: 41.15
+	Sc
		987754 GPN3_YEAST (20-271): 3.94e-93: 281: 23.86		GPN2_YEAST (3-254): 8.37e-105: 310: 34.35