HitPredict

Interactor 1: SYF1 (Q9HCS7)
Pre-mRNA-splicing factor SYF1 (Protein HCNP) (XPA-binding protein 2)
Gene: XAB2

Interactor 2: PPIE (Q9UNP9)
Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Cyclophilin-33) (Rotamase E)
Gene: PPIE

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.759

Property	Details
Experiments	25416956, 26186194, 16189514, 28514442, 24981860, 33961781, 22365833, 32296183, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation, tandem affinity purification, two hybrid pooling approach
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0043231 - intracellular membrane-bounded organelle GO:0071007 - U2-type catalytic step 2 spliceosome and 1 others more... GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 855 Hs			1 301
+	Hs
		1318165 CRNL1_HUMAN (166-822): 5.62e-47: 182: 14.51		PPIE_HUMAN (1-301): 5.5e-108: 317: 100.00
+	Hs
		300288 PRP6_HUMAN (2-353): 4.69e-26: 117: 12.92		PPIE_HUMAN (1-301): 5.5e-108: 317: 100.00
+	Ce
		954283 P91175_CAEEL (1-617): 1.55e-26: 118: 12.50		Q9U2S6_CAEEL (3-300): 6.63e-96: 288: 59.40
+	Hs
		203523 SART3_HUMAN (18-578): 1.7e-31: 134: 12.80		PPIH_HUMAN (131-300): 1.25e-91: 271: 55.11
+	Dm
		54167 SYF1_DROME (1-255): 9.35e-16: 83.9: 13.69		PPIE_DROME (1-300): 2.1e-104: 308: 64.67
+	Hs
		923658 CSTF3_HUMAN (11-543): 2.99e-35: 145: 13.25		PPIA_HUMAN (137-300): 3.31e-63: 198: 66.46
+	Dm
		1180641 Q7KJA9_DROME (406-768): 3.13e-33: 140: 13.50		Q9W227_DROME (143-300): 3.52e-59: 189: 55.35