HitPredict

Interactor 1: HYOU1 (Q9JKR6)
Hypoxia up-regulated protein 1 (GRP-170) (140 kDa Ca(2+)-binding protein) (CBP-140)
Gene: HYOU1

Interactor 2: CHIP (Q9WUD1)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)
Gene: Stub1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24218449
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ANAPC3~HSP70
Common GO terms	GO:0002931 - response to ischemia GO:0030968 - endoplasmic reticulum unfolded protein response GO:0071456 - cellular response to hypoxia
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 999 Mm			1 304
+	Hs
		714464 HSP74_HUMAN (33-959): 0: 785: 25.78		CHIP_HUMAN (1-304): 9.07e-67: 212: 97.04
+	Hs
		320929 HS74L_HUMAN (33-955): 0: 755: 24.92		CHIP_HUMAN (1-304): 9.07e-67: 212: 97.04
+	Hs
		714148 HSP74_HUMAN (33-959): 0: 785: 25.78		PPP5_HUMAN (1-260): 1.89e-35: 135: 20.76
+	Hs
		685137 HYOU1_HUMAN (1-999): 0: 801: 92.09		STIP1_HUMAN (3-263): 8.89e-13: 70.4: 10.14
+	Hs
		1290190 HYOU1_HUMAN (1-999): 0: 801: 92.09		SGTB_HUMAN (3-175): 5.87e-12: 67: 14.05
+	Hs
		684440 HSP74_HUMAN (33-959): 0: 785: 25.78		STIP1_HUMAN (3-263): 8.89e-13: 70.4: 10.14
+	Hs
		684925 HS105_HUMAN (33-949): 0: 784: 26.03		STIP1_HUMAN (3-263): 8.89e-13: 70.4: 10.14
+	Hs
		213491 HSP74_HUMAN (33-959): 0: 785: 25.78		SGTA_HUMAN (72-173): 1.97e-09: 59.6: 15.69
+	Mm
		821833 HS74L_MOUSE (33-958): 0: 769: 25.70		WDTC1_MOUSE (25-140): 3.28e-09: 59.7: 31.50
+	Hs
		320819 HS74L_HUMAN (33-955): 0: 755: 24.92		STIP1_HUMAN (3-263): 8.89e-13: 70.4: 10.14
+	Hs
		213427 HS74L_HUMAN (33-955): 0: 755: 24.92		SGTA_HUMAN (72-173): 1.97e-09: 59.6: 15.69
+	Dm
		1365847 HSP74_DROME (33-557): 3.67e-65: 234: 32.77		Q9XYW6_DROME (29-304): 6.33e-58: 189: 57.61
+	Dm
		1213535 HSP72_DROME (33-557): 4.77e-65: 233: 32.77		Q9XYW6_DROME (29-304): 6.33e-58: 189: 57.61
+	Dm
		365423 HSP71_DROME (33-557): 2.1e-64: 231: 32.58		Q9XYW6_DROME (29-304): 6.33e-58: 189: 57.61
+	Dm
		947912 HSP70_DROME (33-557): 2.1e-64: 231: 32.58		Q9XYW6_DROME (29-304): 6.33e-58: 189: 57.61
+	Dm
		365404 HSP71_DROME (33-557): 2.1e-64: 231: 32.58		Q9V3E9_DROME (10-252): 7.2e-34: 131: 17.48
+	At
		1338010 HS704_ARATH (688-846): 1.39e-39: 158: 17.61		CHIP_ARATH (27-301): 3.85e-48: 164: 31.41
+	At
		612321 HS701_ARATH (688-847): 3.43e-40: 160: 16.88		OE64C_ARATH (23-131): 8.14e-42: 153: 32.11
+	At
		99225 HS701_ARATH (688-847): 3.43e-40: 160: 16.88		OE64M_ARATH (23-142): 5.82e-32: 126: 28.33
+	At
		1338008 HS704_ARATH (688-846): 1.39e-39: 158: 17.61		HSOP1_ARATH (3-288): 6.12e-10: 61.9: 9.54