HitPredict

Interactor 1: FBXW4 (Q9JMJ2)
F-box/WD repeat-containing protein 4 (F-box and WD-40 domain-containing protein 4) (Protein hagoromo)
Gene: FBXW4

Interactor 2: SKP1 (Q9WTX5)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (S-phase kinase-associated protein 1A) (p19A) (p19skp1)
Gene: SKP1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11735228
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	F-box-like~Skp1
Common GO terms	GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 410 Mm			1 163
+	Hs
		885030 FBXW4_HUMAN (19-410): 1.3e-84: 265: 91.60		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Mm
		1112932 FBW1A_MOUSE (26-410): 1.83e-79: 258: 15.81		SKP1_MOUSE (1-163): 3.56e-91: 263: 100.00
+	Xl
		1174984 TRCB_XENLA (26-410): 2.9e-79: 255: 16.05		SKP1_XENLA (1-163): 5.9e-91: 263: 99.39
+	Mm
		1257397 FBXW7_MOUSE (47-274): 2.4e-44: 165: 14.83		SKP1_MOUSE (1-163): 3.56e-91: 263: 100.00
+	Hs
		929021 FBXW7_HUMAN (47-274): 6.6e-44: 164: 14.83		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Sp
		1000009 POF11_SCHPO (101-367): 5.58e-52: 183: 21.30		SKP1_SCHPO (1-163): 1.77e-74: 221: 56.36
+	Mm
		1131317 FBW1B_MOUSE (225-409): 8.3e-32: 128: 12.77		SKP1_MOUSE (1-163): 3.56e-91: 263: 100.00
+	Dm
		285042 FBXW7_DROME (47-282): 3.57e-39: 151: 15.92		O77430_DROME (1-163): 3.96e-82: 240: 76.07
+	Hs
		929110 FBW1B_HUMAN (225-409): 1.13e-31: 127: 12.77		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Sp
		953229 POF1_SCHPO (226-409): 6.21e-33: 132: 16.85		SKP1_SCHPO (1-163): 1.77e-74: 221: 56.36
+	Ce
		105479 SEL10_CAEEL (283-409): 2.57e-24: 106: 12.60		SKR1_CAEEL (4-162): 1.3e-80: 237: 70.81
+	Dm
		218244 O44382_DROME (274-410): 1.33e-22: 101: 15.22		O77430_DROME (1-163): 3.96e-82: 240: 76.07
+	Dm
		285012 Q9VDE3_DROME (274-410): 1.43e-22: 101: 15.22		O77430_DROME (1-163): 3.96e-82: 240: 76.07
+	Hs
		929125 FBW1A_HUMAN (37-153): 4.41e-13: 72.9: 12.80		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Dm
		1180601 Q9VDE3_DROME (274-410): 1.43e-22: 101: 15.22		Q7KJ69_DROME (1-163): 1.72e-76: 226: 67.49
+	Ce
		105997 LIN23_CAEEL (288-410): 3.42e-23: 103: 13.82		G5EDD8_CAEEL (4-162): 4.74e-67: 203: 60.25
+	Sc
		759309 MET30_YEAST (40-317): 7.73e-22: 99.9: 14.51		SKP1_YEAST (4-163): 2.12e-66: 202: 42.63
+	Dm
		1363661 Q9VDE3_DROME (274-410): 1.43e-22: 101: 15.22		Q9VWC4_DROME (2-153): 2.29e-65: 198: 56.86
+	Sc
		431143 CDC4_YEAST (194-409): 1.09e-19: 93.4: 15.55		SKP1_YEAST (4-163): 2.12e-66: 202: 42.63
+	Sp
		144900 POP2_SCHPO (150-347): 1.64e-12: 71: 15.42		SKP1_SCHPO (1-163): 1.77e-74: 221: 56.36