HitPredict

Interactor 1: SOX1 (O00570)
Transcription factor SOX-1
Gene: SOX1

Interactor 2: CTNB1 (P35222)
Catenin beta-1 (Beta-catenin)
Gene: CTNNB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22767186
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Arm~HMG_box
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0002089 - lens morphogenesis in camera-type eye GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 391 Hs			1 781
+	Hs
		717031 SSRP1_HUMAN (30-211): 5.5e-34: 135: 15.93		CTNB1_HUMAN (1-781): 0: 626: 100.00
+	Hs
		716868 SOX2_HUMAN (5-391): 1.67e-35: 134: 43.56		CTNB1_HUMAN (1-781): 0: 626: 100.00
+	Hs
		716923 SOX10_HUMAN (38-391): 1.98e-34: 134: 24.23		CTNB1_HUMAN (1-781): 0: 626: 100.00
+	Mm
		970139 SOX17_MOUSE (9-359): 1.52e-33: 131: 24.18		CTNB1_MOUSE (1-781): 0: 624: 99.87
+	Hs
		717348 SOX17_HUMAN (9-366): 6.25e-31: 124: 22.80		CTNB1_HUMAN (1-781): 0: 626: 100.00
+	Mm
		818698 SOX2_MOUSE (5-391): 1.04e-32: 126: 43.30		CTNB1_MOUSE (1-781): 0: 624: 99.87
+	Mm
		776233 SOX6_MOUSE (26-222): 2.57e-30: 124: 26.40		CTNB1_MOUSE (1-781): 0: 624: 99.87
+	Hs
		716823 SOX6_HUMAN (26-223): 6.11e-27: 114: 26.26		CTNB1_HUMAN (1-781): 0: 626: 100.00
+	Dm
		578667 PANG2_DROME (3-383): 1.92e-53: 193: 15.22		ARM_DROME (1-780): 9.15e-160: 486: 64.49
+	Dm
		578629 PANG1_DROME (8-383): 9.17e-41: 155: 15.87		ARM_DROME (1-780): 9.15e-160: 486: 64.49
+	Hs
		134850 SOX2_HUMAN (5-391): 1.67e-35: 134: 43.56		IMA3_HUMAN (198-681): 7.05e-69: 237: 14.34
+	Hs
		853482 HM20A_HUMAN (10-149): 2.56e-27: 112: 21.28		IMA1_HUMAN (237-675): 3.54e-66: 231: 18.54