HitPredict

Interactor 1: SOX1 (O00570)
Transcription factor SOX-1
Gene: SOX1

Interactor 2: SOX5 (P35711)
Transcription factor SOX-5
Gene: SOX5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HMG_box~HMG_box
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 391 Hs			1 763
+	Hs
		727827 SOX13_HUMAN (38-138): 6.09e-38: 146: 43.56		SOX5_HUMAN (1-763): 0: 611: 100.00
+	Hs
		727706 SOX11_HUMAN (39-141): 9.01e-38: 143: 48.54		SOX5_HUMAN (1-763): 0: 611: 100.00
+	Hs
		727704 SOX5_HUMAN (21-185): 1.95e-34: 137: 34.55		SOX5_HUMAN (1-763): 0: 611: 100.00
+	Hs
		727941 SOX13_HUMAN (38-138): 6.09e-38: 146: 43.56		SOX6_HUMAN (14-763): 6.99e-144: 444: 56.44
+	Hs
		727705 SOX5_HUMAN (21-185): 1.95e-34: 137: 34.55		SOX6_HUMAN (14-763): 6.99e-144: 444: 56.44
+	Dm
		1212946 PANG2_DROME (3-383): 1.92e-53: 193: 15.22		PANG2_DROME (63-630): 4.71e-101: 339: 15.64
+	Hs
		1357429 SOX13_HUMAN (38-138): 6.09e-38: 146: 43.56		SOX13_HUMAN (107-730): 3.41e-75: 257: 42.52
+	Hs
		133761 SOX1_HUMAN (1-391): 2.31e-53: 183: 100.00		SOX2_HUMAN (520-642): 2.65e-36: 141: 38.10
+	Dm
		954936 PANG1_DROME (8-383): 9.17e-41: 155: 15.87		PANG1_DROME (243-630): 8.32e-41: 162: 18.04
+	Dm
		1212959 PANG2_DROME (3-383): 1.92e-53: 193: 15.22		Q9VUD3_DROME (513-675): 1.33e-26: 117: 33.13
+	Dm
		114544 M9PCZ7_DROME (21-329): 4.75e-39: 150: 35.60		M9PFG6_DROME (538-638): 1.17e-40: 156: 44.55
+	Dm
		114457 PANG1_DROME (8-383): 9.17e-41: 155: 15.87		M9PCG2_DROME (523-636): 3.38e-37: 149: 44.74
+	Hs
		727966 SOX13_HUMAN (38-138): 6.09e-38: 146: 43.56		SOX11_HUMAN (535-639): 1.28e-36: 145: 46.67
+	Hs
		727788 SOX5_HUMAN (21-185): 1.95e-34: 137: 34.55		CIC_HUMAN (305-752): 1.22e-35: 147: 15.96
+	Hs
		727709 SOX5_HUMAN (21-185): 1.95e-34: 137: 34.55		SOX2_HUMAN (520-642): 2.65e-36: 141: 38.10
+	Hs
		727795 SOX5_HUMAN (21-185): 1.95e-34: 137: 34.55		SOX7_HUMAN (516-723): 1.22e-32: 132: 30.70
+	Dm
		115539 M9PFG6_DROME (32-180): 6.75e-38: 142: 57.72		DICH_DROME (474-706): 3.29e-27: 116: 23.93
+	Hs
		727808 SOX5_HUMAN (21-185): 1.95e-34: 137: 34.55		HM20A_HUMAN (457-654): 6.16e-29: 120: 11.94