HitPredict

Interactor 1: DDX3X (O00571)
ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2)
Gene: DDX3X

Interactor 2: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25948554, 22412018
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0010628 - positive regulation of gene expression
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 662 Hs			1 664
+	Hs
		133866 DDX3X_HUMAN (1-662): 0: 614: 100.00		K2C5_HUMAN (24-390): 2.24e-117: 364: 25.95
+	Hs
		133822 DDX3X_HUMAN (1-662): 0: 614: 100.00		K2C6A_HUMAN (23-407): 5.26e-116: 360: 23.71
+	Hs
		133831 DDX3X_HUMAN (1-662): 0: 614: 100.00		K2C6B_HUMAN (24-407): 5.03e-115: 357: 23.51
+	Mm
		821712 DDX3Y_MOUSE (1-662): 0: 587: 89.89		LMNA_MOUSE (1-664): 1.23e-70: 243: 94.90
+	Hs
		359643 DDX5_HUMAN (90-658): 2.78e-160: 476: 35.70		LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00
+	Hs
		360112 DDX42_HUMAN (8-654): 8.9e-153: 467: 26.77		LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00
+	Ce
		1094241 Q9N3F4_CAEEL (105-651): 3.6e-159: 474: 51.73		LMN1_CAEEL (1-539): 1.07e-53: 195: 29.49
+	Ce
		1094229 Q65XX1_CAEEL (100-651): 8.26e-159: 473: 51.26		LMN1_CAEEL (1-539): 1.07e-53: 195: 29.49
+	Ce
		1094235 Q95XY1_CAEEL (105-651): 5.4e-158: 471: 51.64		LMN1_CAEEL (1-539): 1.07e-53: 195: 29.49
+	Dr
		71439 F1QSB8_DANRE (8-654): 2.23e-148: 455: 26.57		B3DKC5_DANRE (9-597): 8e-53: 194: 65.08