HitPredict

Interactor 1: DDX3X (O00571)
ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2)
Gene: DDX3X

Interactor 2: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	29884807, 27460707
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 662 Hs			1 526
+	Hs
		134145 DDX3X_HUMAN (1-662): 0: 614: 100.00		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		133984 DDX3X_HUMAN (1-662): 0: 614: 100.00		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Hs
		134252 DDX3X_HUMAN (1-662): 0: 614: 100.00		PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46
+	Hs
		134018 DDX3X_HUMAN (1-662): 0: 614: 100.00		PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00
+	Hs
		133858 DDX3X_HUMAN (1-662): 0: 614: 100.00		PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44
+	Hs
		571537 DDX5_HUMAN (90-658): 2.78e-160: 476: 35.70		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		1204682 DDX42_HUMAN (8-654): 8.9e-153: 467: 26.77		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		571333 DDX5_HUMAN (90-658): 2.78e-160: 476: 35.70		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Hs
		1271148 DDX17_HUMAN (122-661): 2.1e-152: 459: 36.38		RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10
+	Hs
		726912 DDX42_HUMAN (8-654): 8.9e-153: 467: 26.77		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Hs
		726967 DDX17_HUMAN (122-661): 2.1e-152: 459: 36.38		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Hs
		571409 DDX5_HUMAN (90-658): 2.78e-160: 476: 35.70		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Hs
		571634 DDX5_HUMAN (90-658): 2.78e-160: 476: 35.70		PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46
+	Hs
		967316 DDX17_HUMAN (122-661): 2.1e-152: 459: 36.38		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Hs
		571648 DDX5_HUMAN (90-658): 2.78e-160: 476: 35.70		RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35
+	Hs
		1271695 DDX17_HUMAN (122-661): 2.1e-152: 459: 36.38		PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46
+	Sc
		376580 DED1_YEAST (10-633): 3.96e-151: 452: 47.28		PABP_YEAST (263-381): 1.57e-10: 65.5: 18.49