HitPredict

Interactor 1: DDX3X (O00571)
ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2)
Gene: DDX3X

Interactor 2: IF4G1 (Q04637)
Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220)
Gene: EIF4G1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

The method score is based on:

Property	Details
Experiments	24248602, 22872150
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	DEAD~MA3, DEAD~MIF4G, Helicase_C~MA3, Helicase_C~MIF4G
Common GO terms	GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm and 8 others more... GO:0005829 - cytosol GO:0006413 - translational initiation GO:0008190 - eukaryotic initiation factor 4E binding GO:0010494 - cytoplasmic stress granule GO:0030307 - positive regulation of cell growth GO:0031369 - translation initiation factor binding GO:0036493 - positive regulation of translation in response to endoplasmic reticulum stress GO:1900087 - positive regulation of G1/S transition of mitotic cell cycle
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1	662
Hs

1	1599

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024