HitPredict

Interactor 1: DDX3X (O00571)
ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2)
Gene: DDX3X

Interactor 2: MAVS (Q7Z434)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.631

The method score is based on:

Property	Details
Experiments	27980081, 20127681
Identification Methods	pull down, affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0032481 - positive regulation of type I interferon production GO:0032727 - positive regulation of interferon-alpha production GO:0032728 - positive regulation of interferon-beta production GO:0035591 - signaling adaptor activity GO:0045087 - innate immune response and 3 others more... GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0071651 - positive regulation of chemokine (C-C motif) ligand 5 production GO:1900227 - positive regulation of NLRP3 inflammasome complex assembly
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	662
Hs

1	540

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024