HitPredict

Interactor 1: DDX3X (O00571)
ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2)
Gene: DDX3X

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	21182203
Identification Methods	affinity chromatography technology
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0030308 - negative regulation of cell growth GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 662 Hs			1 530
+	Hs
		133828 DDX3X_HUMAN (1-662): 0: 614: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		181675 DDX3Y_HUMAN (1-662): 0: 602: 91.84		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		133914 DDX3X_HUMAN (1-662): 0: 614: 100.00		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Mm
		509320 DDX3X_MOUSE (1-662): 0: 611: 98.64		RARA_MOUSE (52-508): 5.87e-105: 324: 23.58
+	Hs
		133881 DDX3X_HUMAN (1-662): 0: 614: 100.00		NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30
+	Hs
		181691 DDX3Y_HUMAN (1-662): 0: 602: 91.84		ERR3_HUMAN (60-499): 2.69e-106: 327: 30.29
+	Hs
		368944 DDX5_HUMAN (90-658): 2.78e-160: 476: 35.70		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		370142 DDX17_HUMAN (122-661): 2.1e-152: 459: 36.38		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Mm
		509328 Q8BTS0_MOUSE (90-658): 2.61e-160: 476: 35.70		RARA_MOUSE (52-508): 5.87e-105: 324: 23.58
+	Hs
		571310 DDX5_HUMAN (90-658): 2.78e-160: 476: 35.70		NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30
+	Hs
		133840 DDX3X_HUMAN (1-662): 0: 614: 100.00		PRGR_HUMAN (149-459): 2.26e-41: 161: 32.82
+	Hs
		133853 DDX3X_HUMAN (1-662): 0: 614: 100.00		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		414435 DDX5_HUMAN (90-658): 2.78e-160: 476: 35.70		PRGR_HUMAN (149-459): 2.26e-41: 161: 32.82
+	Hs
		487111 DDX5_HUMAN (90-658): 2.78e-160: 476: 35.70		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487570 DDX42_HUMAN (8-654): 8.9e-153: 467: 26.77		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		571644 DDX5_HUMAN (90-658): 2.78e-160: 476: 35.70		NR2E1_HUMAN (149-408): 2.63e-35: 137: 31.82
+	Hs
		487641 DDX17_HUMAN (122-661): 2.1e-152: 459: 36.38		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59