HitPredict

Interactor 1: WDR6 (Q9NNW5)
tRNA (34-2'-O)-methyltransferase regulator WDR6 (WD repeat-containing protein 6)
Gene: WDR6

Interactor 2: DYR1B (Q9Y463)
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Minibrain-related kinase) (Mirk protein kinase)
Gene: DYRK1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	23602568
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1121 Hs			1 629
+	Hs
		1044171 WDR6_HUMAN (1-1121): 0: 745: 100.00		DYR1A_HUMAN (19-594): 3.53e-135: 415: 63.57
+	Hs
		1242900 WDR6_HUMAN (1-1121): 0: 745: 100.00		HIPK4_HUMAN (111-440): 1.6e-50: 186: 37.68
+	Hs
		1044288 FBW1A_HUMAN (30-284): 7.71e-34: 140: 13.41		DYR1A_HUMAN (19-594): 3.53e-135: 415: 63.57
+	Hs
		929595 RACK1_HUMAN (196-523): 2.91e-47: 173: 17.21		DYRK2_HUMAN (9-492): 1.61e-117: 364: 34.09
+	Hs
		625337 RACK1_HUMAN (196-523): 2.91e-47: 173: 17.21		CDK2_HUMAN (108-376): 5.32e-119: 357: 27.82
+	Hs
		682082 FBW1A_HUMAN (30-284): 7.71e-34: 140: 13.41		AKT1_HUMAN (6-429): 7.87e-119: 363: 18.41
+	Hs
		415113 FBW1A_HUMAN (30-284): 7.71e-34: 140: 13.41		CDK1_HUMAN (108-434): 4.87e-121: 362: 27.76
+	At
		1105782 TPR2_ARATH (21-644): 8.44e-36: 149: 10.57		KSG7_ARATH (111-475): 9.76e-115: 349: 27.11
+	Hs
		1044022 FBXW7_HUMAN (603-914): 3.98e-13: 76: 13.75		DYR1A_HUMAN (19-594): 3.53e-135: 415: 63.57
+	Hs
		254043 WDR1_HUMAN (538-1119): 1.07e-31: 134: 9.41		CDK2_HUMAN (108-376): 5.32e-119: 357: 27.82
+	Hs
		1074800 TAF5_HUMAN (191-376): 1.08e-13: 77.9: 23.71		DYRK2_HUMAN (9-492): 1.61e-117: 364: 34.09
+	Hs
		1268574 FBXW7_HUMAN (603-914): 3.98e-13: 76: 13.75		DYRK2_HUMAN (9-492): 1.61e-117: 364: 34.09
+	Hs
		681967 FBXW7_HUMAN (603-914): 3.98e-13: 76: 13.75		AKT1_HUMAN (6-429): 7.87e-119: 363: 18.41
+	Hs
		415016 FBXW7_HUMAN (603-914): 3.98e-13: 76: 13.75		CDK1_HUMAN (108-434): 4.87e-121: 362: 27.76
+	Hs
		625543 FBXW7_HUMAN (603-914): 3.98e-13: 76: 13.75		CDK2_HUMAN (108-376): 5.32e-119: 357: 27.82
+	At
		1106372 LST81_ARATH (137-308): 8.15e-13: 72.5: 22.16		MPK4_ARATH (114-451): 2.49e-118: 358: 26.65
+	Hs
		1329784 FBW1A_HUMAN (30-284): 7.71e-34: 140: 13.41		HIPK2_HUMAN (111-434): 3.93e-52: 196: 36.31
+	Dm
		1363665 Q9VDE3_DROME (132-344): 9.8e-13: 74.1: 16.82		Q9W0Q1_DROME (111-434): 4.48e-55: 204: 38.21
+	Hs
		1281385 FBXW7_HUMAN (603-914): 3.98e-13: 76: 13.75		HIPK2_HUMAN (111-434): 3.93e-52: 196: 36.31
+	Hs
		833786 GEMI5_HUMAN (758-1120): 9.39e-16: 85.1: 9.37		CLK1_HUMAN (64-431): 1.5e-49: 181: 31.14