HitPredict

Interactor 1: SH22A (Q9NP31)
SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein)
Gene: SH2D2A

Interactor 2: M3K2 (Q9Y2U5)
Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2)
Gene: MAP3K2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	11073940
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 389 Hs			1 619
+	Hs
		433969 LYN_HUMAN (9-313): 7.12e-48: 171: 14.82		M3K3_HUMAN (1-615): 1.07e-179: 524: 64.59
+	Hs
		412388 FYN_HUMAN (38-280): 1.65e-45: 165: 15.67		PAK5_HUMAN (4-617): 9.48e-130: 399: 20.21
+	Hs
		433739 LYN_HUMAN (9-313): 7.12e-48: 171: 14.82		PAK1_HUMAN (96-617): 8.05e-126: 383: 23.83
+	Hs
		924536 GRB2_HUMAN (56-256): 4.42e-50: 169: 15.71		PAK1_HUMAN (96-617): 8.05e-126: 383: 23.83
+	Hs
		522955 SRC_HUMAN (21-280): 1.14e-48: 174: 17.73		PAK2_HUMAN (106-617): 1.52e-123: 377: 24.32
+	Hs
		433609 LYN_HUMAN (9-313): 7.12e-48: 171: 14.82		AKT2_HUMAN (297-616): 5.53e-125: 379: 26.30
+	Hs
		433740 LYN_HUMAN (9-313): 7.12e-48: 171: 14.82		PAK2_HUMAN (106-617): 1.52e-123: 377: 24.32
+	Hs
		924538 GRB2_HUMAN (56-256): 4.42e-50: 169: 15.71		PAK2_HUMAN (106-617): 1.52e-123: 377: 24.32
+	Hs
		433338 YES_HUMAN (7-280): 2.56e-46: 168: 16.56		PAK2_HUMAN (106-617): 1.52e-123: 377: 24.32
+	Hs
		412169 FYN_HUMAN (38-280): 1.65e-45: 165: 15.67		PAK2_HUMAN (106-617): 1.52e-123: 377: 24.32
+	Hs
		442822 HCK_HUMAN (6-212): 2.97e-45: 165: 15.93		PAK2_HUMAN (106-617): 1.52e-123: 377: 24.32
+	Hs
		411702 LCK_HUMAN (22-210): 4.42e-45: 164: 17.31		PAK2_HUMAN (106-617): 1.52e-123: 377: 24.32
+	Hs
		796560 KSYK_HUMAN (94-213): 1.09e-17: 86.9: 23.81		PAK2_HUMAN (106-617): 1.52e-123: 377: 24.32
+	Hs
		924541 GRB2_HUMAN (56-256): 4.42e-50: 169: 15.71		M3K1_HUMAN (351-613): 5.82e-51: 192: 42.13